CAJ | 학술논문

目的：探讨舒必利对心境障碍轻、中度抑郁发作患者的治疗效果。方法将65例门诊和住院心境障碍轻、中度抑郁发作患者随机分为研究组和对照组，分别服用舒必利和氟西汀，研究组33例，对照组32例。应用汉密尔顿抑郁量表(HAMD-17)、汉密尔顿焦虑量表(HAMA)、Bech-Rafaelsen 躁狂量表(BRMS)评定疗效和躁狂转换风险，应用不良反应量表( TESS)、糖脂代谢生化指标和体重指数评定不良事件。结果 HAMD-17和 HAMA 评分同组比较，研究组治疗2周与治疗前比较差异有显著性，两组治疗4周、8周、12周与治疗前比较差异均有显著性；BRMS 评分治疗8周、12周与治疗前比较差异有显著性；两组组间治疗前比较差异无显著性，治疗2周 HAMD、HAMA 评分比较差异有显著性；治疗8周、12周 BRMS 评分两组间及对照组与治疗前比较差异均有显著性。 TESS 统计两组不良事件相当。结论舒必利对心境障碍轻、中度抑郁发作有较好的治疗效果，起效快，安全性好，转躁风险小。
목적：탐토서필리대심경장애경、중도억욱발작환자적치료효과。방법장65례문진화주원심경장애경、중도억욱발작환자수궤분위연구조화대조조，분별복용서필리화불서정，연구조33례，대조조32례。응용한밀이돈억욱량표(HAMD-17)、한밀이돈초필량표(HAMA)、Bech-Rafaelsen 조광량표(BRMS)평정료효화조광전환풍험，응용불량반응량표( TESS)、당지대사생화지표화체중지수평정불량사건。결과 HAMD-17화 HAMA 평분동조비교，연구조치료2주여치료전비교차이유현저성，량조치료4주、8주、12주여치료전비교차이균유현저성；BRMS 평분치료8주、12주여치료전비교차이유현저성；량조조간치료전비교차이무현저성，치료2주 HAMD、HAMA 평분비교차이유현저성；치료8주、12주 BRMS 평분량조간급대조조여치료전비교차이균유현저성。 TESS 통계량조불량사건상당。결론서필리대심경장애경、중도억욱발작유교호적치료효과，기효쾌，안전성호，전조풍험소。
Objective To investigate the clinical efficacy of sulpiride in the treatment of mood disorder ’ s patients with mild to moderate depression. Method Divided 65 cases mood disorder’s patents with mild to moderate depres-sion of outpatients and inpatients into study group and control group according to the treatment sequence by random-ly,respectively took sulpiride and fluoxetine,study group 33 cases,control group 32 cases. Applied the Hamilton De-pression Scale(HAMD),Hamilton Anxiety Scale(HAMA),Bech-Rafaelsen Mania Rating Scale(BRMS) to assess the efficacy and manic conversion risk. To evaluate the adverse events with The Treatment Emergent Symptom Scale (TESS),glucose and lipid metabolism and biochemical index and body mass index. Result HAMD-17 and HAMA scores compared between the two groups,study group for 2 weeks compared with before treatment had statistical sig-nificance,the scores after treated 4 weeks,8 weeks,12 weeks compared with before treatment there all had statistical significance. The BRMS scores for 8 weeks,12 weeks compared with before treatment had statistical significance,be-tween two groups before treatment showed no statistical significance. In the treatment of 2 weeks HAMD,HAMA score was statistically significant. The BRMS score between the two groups and for 8 weeks,12 weeks compared with before treatment in the control group all had statistical significance. TESS statistics the adverse events of two groups is quite. Conclusion Sulpiride in the treatment of mood disorder’s patients with mild to moderate depression has a better effect,good security,less mania conversion.