中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2014年
8期
74-76
,共3页
陈亮%付杰%陈菲%潘虹%王玲%鞠慧岩%薛晴%贺占举%左文莉%徐阳
陳亮%付傑%陳菲%潘虹%王玲%鞠慧巖%薛晴%賀佔舉%左文莉%徐暘
진량%부걸%진비%반홍%왕령%국혜암%설청%하점거%좌문리%서양
染色体核型%小Y染色体%男性不育症
染色體覈型%小Y染色體%男性不育癥
염색체핵형%소Y염색체%남성불육증
Chromosome configuration%Bit Y chromosome%Male infertility
目的：探讨单纯小Y染色体核型对男性生育障碍的影响及其临床意义。方法：研究对象分为A组（男性不育）及B组（配偶既往不良妊娠史或羊水穿刺示胎儿染色体异常等），比较不同组别间小Y核型的检出率并分析其临床效应。结果：共检出30例小Y核型。其中A组12例，B组18例。两组间小Y核型的检出率没有显著差异（P＝0.971）。小Y核型的临床效应为：无精症、少精症、配偶胚胎停育、自然流产等不良妊娠结局。结论：小Y核型可能具备某些潜在的临床效应，可能会对男性生精过程及配偶的不良妊娠结局产生影响，需要在分子生物学及功能基因组学层面继续深入验证。
目的：探討單純小Y染色體覈型對男性生育障礙的影響及其臨床意義。方法：研究對象分為A組（男性不育）及B組（配偶既往不良妊娠史或羊水穿刺示胎兒染色體異常等），比較不同組彆間小Y覈型的檢齣率併分析其臨床效應。結果：共檢齣30例小Y覈型。其中A組12例，B組18例。兩組間小Y覈型的檢齣率沒有顯著差異（P＝0.971）。小Y覈型的臨床效應為：無精癥、少精癥、配偶胚胎停育、自然流產等不良妊娠結跼。結論：小Y覈型可能具備某些潛在的臨床效應，可能會對男性生精過程及配偶的不良妊娠結跼產生影響，需要在分子生物學及功能基因組學層麵繼續深入驗證。
목적：탐토단순소Y염색체핵형대남성생육장애적영향급기림상의의。방법：연구대상분위A조（남성불육）급B조（배우기왕불량임신사혹양수천자시태인염색체이상등），비교불동조별간소Y핵형적검출솔병분석기림상효응。결과：공검출30례소Y핵형。기중A조12례，B조18례。량조간소Y핵형적검출솔몰유현저차이（P＝0.971）。소Y핵형적림상효응위：무정증、소정증、배우배태정육、자연유산등불량임신결국。결론：소Y핵형가능구비모사잠재적림상효응，가능회대남성생정과정급배우적불량임신결국산생영향，수요재분자생물학급공능기인조학층면계속심입험증。
To investigate the effects of bit Y chromosome configuration on male fertility and to evaluate the relevant clinical significance.Methods:The relevant cases were divided into two groups,where A group included male infertile cases while B group included cases whose wife had adverse pregnancy history or the ab-normal amniotic fluid punctures.Cytogenetics of patients was examined by culturing peripheral-blood lymphocyte and G-banding technology,and karyotyping analysis technique was used to study the bit Y chromosome in two dif-ferent groups.Results:Among the 2139 cases,30 cases were found with abnormal karyotype of bit Y chromo-some.,including 12 ones in group A and 18 ones in group B,with no significant difference (P=0.971).The main clinical effects of bit Y were azoospermia,oligozoospermia,miscarriage,embryonic diapause and fetal anomalies,et al.Conclusion:The bit Y chromosomal abnormality may have some potential clinical effects which may affect the spermatogenesis and adverse pregnancy.Therefore,a detailed mechanism study needs to be further investigated.
