中国性科学
中國性科學
중국성과학
THE CHINESE JOURNAL OF HUMAN SEXUALITY
2014年
8期
27-29
,共3页
围绝经期功能性子宫出血%米非司酮%去氧孕烯炔雌醇片%子宫内膜厚度
圍絕經期功能性子宮齣血%米非司酮%去氧孕烯炔雌醇片%子宮內膜厚度
위절경기공능성자궁출혈%미비사동%거양잉희결자순편%자궁내막후도
Dysfunctional uterine bleeding during peri -menopausal period%Mifepristone%Desogestrel and ethinylestradiol tablets%Endometrial thickness
目的：观察米非司酮与去氧孕烯炔雌醇片对围绝经期功能性子宫出血患者子宫内膜厚度的影响及疗效。方法：选取围绝经期功能性子宫出血患者70例，随机分为观察组和对照组。观察组患者在刮宫术后5d开始口服米非司酮连用3个月。对照组患者在刮宫术后5d开始口服去氧孕烯炔雌醇片连用3个月。观察两组患者治疗前后子宫内膜厚度的变化，并比较其临床疗效及安全性。结果：治疗3个月后，两组患者子宫内膜厚度均较前明显变薄（P＜0.05或P＜0.01），且观察组较对照组变薄更明显（P＜0.05）；治疗后随访6个月，两组患者的临床总有效率比较差异无统计学意义（χ2＝0.27，P＞0.05）。治疗中对照组和观察组分别发生6例和5例不良反应，症状均较轻，两组不良反应发生率比较无明显统计学差异（χ2＝0.11， P＞0.05）。结论：米非司酮与去氧孕烯炔雌醇片治疗围绝经期功能性子宫出血患者均具有较好疗效及安全性，且前者对子宫内膜增生抑制更明显，适用于年龄较大妇女；而后者恢复正常月经周期率高，适用于较年轻有避孕要求的妇女。
目的：觀察米非司酮與去氧孕烯炔雌醇片對圍絕經期功能性子宮齣血患者子宮內膜厚度的影響及療效。方法：選取圍絕經期功能性子宮齣血患者70例，隨機分為觀察組和對照組。觀察組患者在颳宮術後5d開始口服米非司酮連用3箇月。對照組患者在颳宮術後5d開始口服去氧孕烯炔雌醇片連用3箇月。觀察兩組患者治療前後子宮內膜厚度的變化，併比較其臨床療效及安全性。結果：治療3箇月後，兩組患者子宮內膜厚度均較前明顯變薄（P＜0.05或P＜0.01），且觀察組較對照組變薄更明顯（P＜0.05）；治療後隨訪6箇月，兩組患者的臨床總有效率比較差異無統計學意義（χ2＝0.27，P＞0.05）。治療中對照組和觀察組分彆髮生6例和5例不良反應，癥狀均較輕，兩組不良反應髮生率比較無明顯統計學差異（χ2＝0.11， P＞0.05）。結論：米非司酮與去氧孕烯炔雌醇片治療圍絕經期功能性子宮齣血患者均具有較好療效及安全性，且前者對子宮內膜增生抑製更明顯，適用于年齡較大婦女；而後者恢複正常月經週期率高，適用于較年輕有避孕要求的婦女。
목적：관찰미비사동여거양잉희결자순편대위절경기공능성자궁출혈환자자궁내막후도적영향급료효。방법：선취위절경기공능성자궁출혈환자70례，수궤분위관찰조화대조조。관찰조환자재괄궁술후5d개시구복미비사동련용3개월。대조조환자재괄궁술후5d개시구복거양잉희결자순편련용3개월。관찰량조환자치료전후자궁내막후도적변화，병비교기림상료효급안전성。결과：치료3개월후，량조환자자궁내막후도균교전명현변박（P＜0.05혹P＜0.01），차관찰조교대조조변박경명현（P＜0.05）；치료후수방6개월，량조환자적림상총유효솔비교차이무통계학의의（χ2＝0.27，P＞0.05）。치료중대조조화관찰조분별발생6례화5례불량반응，증상균교경，량조불량반응발생솔비교무명현통계학차이（χ2＝0.11， P＞0.05）。결론：미비사동여거양잉희결자순편치료위절경기공능성자궁출혈환자균구유교호료효급안전성，차전자대자궁내막증생억제경명현，괄용우년령교대부녀；이후자회복정상월경주기솔고，괄용우교년경유피잉요구적부녀。
To observe the influence and curative effect of Mifepristone and Desogestrel and Ethinylestradiol Tablets on endometrial thickness of patients with dysfunctional uterine bleeding during peri-meno-pausal period.Methods:70 patients with dysfunctional uterine bleeding during peri-menopausal period were se-lected and divided into observation group and control group randomly.The patients in observation group were given Mifepristone orally 5 days after the uterine curettage for 3 months,while the patients in control group were given Desogestrel and Ethinylestradiol Tablets orally 5 days after the uterine curettage for 3 months.The changes of endo-metrial thickness of patients in two groups after the medical treatment were observed and clinical curative effect and security were compared as well.Results:After 3 months’medical treatment,the endometrial thickness of patients in two groups were obviously thinner (P<0.05 or P<0.01 ),and the extent of thinning in observation group was much more obvious than that it in control group (P<0.05 ).According to the 6 months’following-up after the medical treatment,the total clinical efficiency of patients in two groups had no statistical differences (χ2 =0.27, P>0.05).6 and 5 cases of untoward effect appeared in control group and observation group in the medical treat-ment respectively,with light symptom.The occurrence rates of untoward effect of the two group had no statistical differences (χ2 =0.11,P>0.05).Conclusion:Mifepristone and Desogestrel and Ethinylestradiol Tablets have fa-vorable curative effect and security on patients with dysfunctional uterine bleeding during peri-menopausal period, and the former has much more obvious inhibitory action on hyperplasia endometrium,which is suitable for older women;while the latter has high rate of returning to normal menstrual cycle rate,which is suitable for younger women with contraceptive requirement.
