中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2014年
8期
708-710
,共3页
张连东%裴新军%谭美春%姜颢%张浩
張連東%裴新軍%譚美春%薑顥%張浩
장련동%배신군%담미춘%강호%장호
瘦素(leptin)%慢性阻塞性肺疾病(COPD)%肿瘤坏死因子-α(TNF-α)%C-反应蛋白(CRP)%肺功能%急性加重期
瘦素(leptin)%慢性阻塞性肺疾病(COPD)%腫瘤壞死因子-α(TNF-α)%C-反應蛋白(CRP)%肺功能%急性加重期
수소(leptin)%만성조새성폐질병(COPD)%종류배사인자-α(TNF-α)%C-반응단백(CRP)%폐공능%급성가중기
Leptin%Chronic obstructive pulmonary disease (COPD)%Tumor necrosis factor-α(TNF-α)%C-reactive protein (CRP)%Lung function%Acute exacerabation
目的：探讨血清瘦素（ leptin ）与慢性阻塞性肺疾病（ chronic obstructive pulmonary disease， COPD）急性加重期患者肺功能的关系。方法选择COPD急性加重期患者35例、COPD稳定期患者38例及健康志愿者30例，抽取空腹血。用放免法测定血清瘦素、用酶联免疫吸附法（ELISA）测定肿瘤坏死因子-α（TNF-α）及用全自动生化仪检测C-反应蛋白（CRP）；检测肺功能，记录1 s用力呼气量（ FEVl ）、最大通气量（ MVV）、肺一氧化碳弥散量（ DLCO ）等指标、分析COPD急性加重期患者血清瘦素水平与TNF-α、CRP、肺功能等的相关性。结果①COPD急性加重期患者血清瘦素、TNF-α、CRP均明显高于COPD稳定期组和对照组，而FEVl、MVV、DLCO则明显低于后者；②COPD急性加重期患者血清瘦素与TNF-α、CRP呈正相关，与FEVl、MVV、DLCO呈负相关。结论血清瘦素可判断COPD急性加重期预后，可以评估肺功能损害风险。
目的：探討血清瘦素（ leptin ）與慢性阻塞性肺疾病（ chronic obstructive pulmonary disease， COPD）急性加重期患者肺功能的關繫。方法選擇COPD急性加重期患者35例、COPD穩定期患者38例及健康誌願者30例，抽取空腹血。用放免法測定血清瘦素、用酶聯免疫吸附法（ELISA）測定腫瘤壞死因子-α（TNF-α）及用全自動生化儀檢測C-反應蛋白（CRP）；檢測肺功能，記錄1 s用力呼氣量（ FEVl ）、最大通氣量（ MVV）、肺一氧化碳瀰散量（ DLCO ）等指標、分析COPD急性加重期患者血清瘦素水平與TNF-α、CRP、肺功能等的相關性。結果①COPD急性加重期患者血清瘦素、TNF-α、CRP均明顯高于COPD穩定期組和對照組，而FEVl、MVV、DLCO則明顯低于後者；②COPD急性加重期患者血清瘦素與TNF-α、CRP呈正相關，與FEVl、MVV、DLCO呈負相關。結論血清瘦素可判斷COPD急性加重期預後，可以評估肺功能損害風險。
목적：탐토혈청수소（ leptin ）여만성조새성폐질병（ chronic obstructive pulmonary disease， COPD）급성가중기환자폐공능적관계。방법선택COPD급성가중기환자35례、COPD은정기환자38례급건강지원자30례，추취공복혈。용방면법측정혈청수소、용매련면역흡부법（ELISA）측정종류배사인자-α（TNF-α）급용전자동생화의검측C-반응단백（CRP）；검측폐공능，기록1 s용력호기량（ FEVl ）、최대통기량（ MVV）、폐일양화탄미산량（ DLCO ）등지표、분석COPD급성가중기환자혈청수소수평여TNF-α、CRP、폐공능등적상관성。결과①COPD급성가중기환자혈청수소、TNF-α、CRP균명현고우COPD은정기조화대조조，이FEVl、MVV、DLCO칙명현저우후자；②COPD급성가중기환자혈청수소여TNF-α、CRP정정상관，여FEVl、MVV、DLCO정부상관。결론혈청수소가판단COPD급성가중기예후，가이평고폐공능손해풍험。
Objective To explore the relationship between leptin and the pulmonary function in acute exacerabation of chronic obstructive pulmonary disease ( AECOPD ) .Methods Thirty -five AECOPD patients ( AECOPD group ) , 38 COPD patients in statinary phase ( Statinary group ) and 30 healthy aged people control group were selected in this study .The serum leptin, tumor necrosis factor-α(TNF-α) and C-reactive protein (CRP) were detected.Pulmonary function test was taken.The correlation between the serum leptin level and TNF -α, CRP, lung function index were analyzed . Results ①The serum leptin , CRP and TNF-αin AECOPD group were higher significantly than those in Statinary group and Control group .The pulmonary function index -FEVl, MVV and DLCO were lower significantly than those in Statinary group and Control group .②The serum leptin level in patients with COPD had positive correlation with CRP , TNF-α, and had negative correlation with pulmonary function index-FEVl, MVV and DLCO.Conclusion Leptin is a predictor of COPD, and may be useful for assessing risk of impaired lung function .
