中国急救医学
中國急救醫學
중국급구의학
CHINESE JOURNAL OF CRITICAL CARE MEDICINE
2014年
8期
685-688
,共4页
莫西沙星%社区获得性肺炎(CAP)%老年人%肾功能不全
莫西沙星%社區穫得性肺炎(CAP)%老年人%腎功能不全
막서사성%사구획득성폐염(CAP)%노년인%신공능불전
Moxifloxacinin%Community acquired pneumonia%Elderly patient%Renal dysfunction
目的：评估莫西沙星在老年肾功能不全社区获得性肺炎（ community acquired pneumonia， CAP）中的治疗效果及安全性，为临床治疗老年肾功能不全CAP选择安全、高效的抗菌药物。方法选取2011-01～2013-12在急诊科住院的128例老年CAP患者，根据肾功能状况分为肾功能正常组（n＝63）和肾功能不全但未透析组（n＝65），均给予莫西沙星治疗，观察临床疗效及不良反应。结果肾功能正常组与肾功能不全组比较，治疗有效率（81．0％vs．87．7％，P＝0．294），细菌清除率（80．56％vs．88．37％，P＝0．335），不良反应发生率（7．93％vs．9.23％，P＝0.794）均差异无统计学意义。无论是肾功能正常组，还是肾功能异常组，在整个治疗期间莫西沙星血药浓度保持平稳，两组之间差异无统计学意义（P＞0．05）。结论莫西沙星治疗老年肾功能不全相关肺炎临床效果明显，不良反应少，安全可靠。
目的：評估莫西沙星在老年腎功能不全社區穫得性肺炎（ community acquired pneumonia， CAP）中的治療效果及安全性，為臨床治療老年腎功能不全CAP選擇安全、高效的抗菌藥物。方法選取2011-01～2013-12在急診科住院的128例老年CAP患者，根據腎功能狀況分為腎功能正常組（n＝63）和腎功能不全但未透析組（n＝65），均給予莫西沙星治療，觀察臨床療效及不良反應。結果腎功能正常組與腎功能不全組比較，治療有效率（81．0％vs．87．7％，P＝0．294），細菌清除率（80．56％vs．88．37％，P＝0．335），不良反應髮生率（7．93％vs．9.23％，P＝0.794）均差異無統計學意義。無論是腎功能正常組，還是腎功能異常組，在整箇治療期間莫西沙星血藥濃度保持平穩，兩組之間差異無統計學意義（P＞0．05）。結論莫西沙星治療老年腎功能不全相關肺炎臨床效果明顯，不良反應少，安全可靠。
목적：평고막서사성재노년신공능불전사구획득성폐염（ community acquired pneumonia， CAP）중적치료효과급안전성，위림상치료노년신공능불전CAP선택안전、고효적항균약물。방법선취2011-01～2013-12재급진과주원적128례노년CAP환자，근거신공능상황분위신공능정상조（n＝63）화신공능불전단미투석조（n＝65），균급여막서사성치료，관찰림상료효급불량반응。결과신공능정상조여신공능불전조비교，치료유효솔（81．0％vs．87．7％，P＝0．294），세균청제솔（80．56％vs．88．37％，P＝0．335），불량반응발생솔（7．93％vs．9.23％，P＝0.794）균차이무통계학의의。무론시신공능정상조，환시신공능이상조，재정개치료기간막서사성혈약농도보지평은，량조지간차이무통계학의의（P＞0．05）。결론막서사성치료노년신공능불전상관폐염림상효과명현，불량반응소，안전가고。
Objective To evaluate the effectiveness and safety of moxifloxacinin treatment of community acquired pneumonia in elderly patients with renal dysfunction , so as to provide safe and effective antibiotics for the treatment of community acquired pneumonia for patients . elderly renal dysfunction .Methods A total of 128 elderly patients with community acquired pneumonia , who enrolled the emergency department of the hospital from Jan 2011 to Dec 2013 , were divided into two groups according to the renal function .The normal group ( n =63 ) and the renal dysfunction group without hemodialysis ( n =65 ) were both treated with moxifloxacin .The clinical efficacies and the adverse reactions were observed .Results There was no statistically difference in the clinical effective rates (81.0% vs.87.7%, P=0.294), the pathogensclearance rate (80.56% vs.88.37%, P=0.335) and the incidence of the adverse reactions (7.93% vs.9.23%, P=0.794) between the two groups.There was no significant difference of moxifloxacin plasma concentration between the two groups at each time point.The plasma concentration was stable in the whole protocol .Conclusion Moxifloxacincan achieve good clinic effect in the treatment of community acquired pneumonia with renal dysfunction in elderly patients with less adverse reaction .
