CAJ | 학술논문

目的探讨双黄连联合左氧氟沙星对兔组织笼感染模型中金黄色葡萄球菌ATCC29213对左氧氟沙星的耐药性的影响。方法建立兔组织笼感染模型,分别用左氧氟沙星单独处理(A组)及双黄连联合左氧氟沙星处理(B组)5 d,探讨兔组织笼感染模型中左氧氟沙星在组织液中稳态浓度及经处理后兔组织笼中细菌恢复生长的情况和细菌耐药性变化。结果两组左氧氟沙星在组织液中浓度差异无统计学意义。 B组兔组织笼内细菌恢复生长发生率(20%)明显低于A组(100.0%),而左氧氟沙星对B组兔组织笼内细菌的最低抑菌浓度(MIC)值明显低于A组。结论双黄连与左氧氟沙星联合治疗有助于减少金黄色葡萄球菌对左氧氟沙星的耐药现象,提示中药联合抗菌药物可降低细菌对抗菌药物的耐药性。
목적탐토쌍황련연합좌양불사성대토조직롱감염모형중금황색포도구균ATCC29213대좌양불사성적내약성적영향。방법건립토조직롱감염모형,분별용좌양불사성단독처리(A조)급쌍황련연합좌양불사성처리(B조)5 d,탐토토조직롱감염모형중좌양불사성재조직액중은태농도급경처리후토조직롱중세균회복생장적정황화세균내약성변화。결과량조좌양불사성재조직액중농도차이무통계학의의。 B조토조직롱내세균회복생장발생솔(20%)명현저우A조(100.0%),이좌양불사성대B조토조직롱내세균적최저억균농도(MIC)치명현저우A조。결론쌍황련여좌양불사성연합치료유조우감소금황색포도구균대좌양불사성적내약현상,제시중약연합항균약물가강저세균대항균약물적내약성。
Objective To explore effects of shuanghuanglian combined with levofloxacin on antibiotic resistance of Staphylococcus Aureus ATCC29213 to levofloxacin. Methods Tissue cage infection model with Staphylococcus aureus was established in rabbits, and the infected animals were given with levofloxacin alone ( group A ) or in combination with shuanghuanglian ( group B) for 5 days respectively. Steady-state concentration of levofloxacin in tissue cage, bacteria recovery and bacterial resistance in tissue cage infection model were studied. Results Steady-state concentration of levofloxacin in tissue cage was not significantly different between group A and group B. The recovery rate of bacteria was significantly lower in group B than in group A (20. 0% vs. 100. 0%). The minimum inhibitory concentration (MIC) was lower in group B than in group A. Conclusion Shuanghuanglian combined with levofloxacin is helpful to reduce antibiotic resistance of Staphylococcus aureus to levofloxacin, indicating that some Chinese traditional medicine combined with antibiotics can reduce antibiotic resistance.