中华精神科杂志
中華精神科雜誌
중화정신과잡지
CHINESE JOURNA OF PSYCHIATRY
2009年
3期
142-145
,共4页
甘景梨%段惠峰%杨家明%高存友%张东卫%蒋占魁%王志娟%马誉%史振娟
甘景梨%段惠峰%楊傢明%高存友%張東衛%蔣佔魁%王誌娟%馬譽%史振娟
감경리%단혜봉%양가명%고존우%장동위%장점괴%왕지연%마예%사진연
精神分裂症%磁共振波谱学%额叶%丘脑
精神分裂癥%磁共振波譜學%額葉%丘腦
정신분렬증%자공진파보학%액협%구뇌
Schizophrenia%Magnetic resonace spectroscopy%Frontal lobe%Thalamus
目的 探讨精神分裂症患者前额叶、丘脑的氢质子磁共振波谱(1H-MRS)的特点.方法 以38例精神分裂症患者为研究对象(患者组),以38名正常人为对照组.两组对象在入组24 h内采用多体素1H-MRS检测前额叶和丘脑N-乙酰基天门冬氨酸(NAA)、胆碱复合物(Cho)与肌酸复合物(Cr),完成NAA/Cr值、Cho/Cr值和NAA/(Cho+Cr)值的计算.采用t检验进行分析.结果 组间比较,患者组左侧前额叶及左、右侧丘脑NAA/Cr值(分别为1.32±0.36,1.53±0.30.1.48±0.37)均低于对照组(分别为1.74±0.27,1.72±0.26,1.73±0.29),差异均有统计学意义(t检验;P均<0.05);患者组左侧前额叶NAA/(Cho+Cr)值(0.64 4±0.13)低于对照组(0.74±0.22),差异有统计学意义(t=2.26,P<0.05).组内比较,患者组和对照组的前额叶及丘脑左、右两侧各生化物质代谢指标的差异均无统计学意义(t检验;P均>0.05).结论 精神分裂症患者存在前额叶及丘脑神经元的功能和(或)结构异常,精神分裂症患者和正常人脑部NAA、Cho、Cr可能并不存在侧化现象.
目的 探討精神分裂癥患者前額葉、丘腦的氫質子磁共振波譜(1H-MRS)的特點.方法 以38例精神分裂癥患者為研究對象(患者組),以38名正常人為對照組.兩組對象在入組24 h內採用多體素1H-MRS檢測前額葉和丘腦N-乙酰基天門鼕氨痠(NAA)、膽堿複閤物(Cho)與肌痠複閤物(Cr),完成NAA/Cr值、Cho/Cr值和NAA/(Cho+Cr)值的計算.採用t檢驗進行分析.結果 組間比較,患者組左側前額葉及左、右側丘腦NAA/Cr值(分彆為1.32±0.36,1.53±0.30.1.48±0.37)均低于對照組(分彆為1.74±0.27,1.72±0.26,1.73±0.29),差異均有統計學意義(t檢驗;P均<0.05);患者組左側前額葉NAA/(Cho+Cr)值(0.64 4±0.13)低于對照組(0.74±0.22),差異有統計學意義(t=2.26,P<0.05).組內比較,患者組和對照組的前額葉及丘腦左、右兩側各生化物質代謝指標的差異均無統計學意義(t檢驗;P均>0.05).結論 精神分裂癥患者存在前額葉及丘腦神經元的功能和(或)結構異常,精神分裂癥患者和正常人腦部NAA、Cho、Cr可能併不存在側化現象.
목적 탐토정신분렬증환자전액협、구뇌적경질자자공진파보(1H-MRS)적특점.방법 이38례정신분렬증환자위연구대상(환자조),이38명정상인위대조조.량조대상재입조24 h내채용다체소1H-MRS검측전액협화구뇌N-을선기천문동안산(NAA)、담감복합물(Cho)여기산복합물(Cr),완성NAA/Cr치、Cho/Cr치화NAA/(Cho+Cr)치적계산.채용t검험진행분석.결과 조간비교,환자조좌측전액협급좌、우측구뇌NAA/Cr치(분별위1.32±0.36,1.53±0.30.1.48±0.37)균저우대조조(분별위1.74±0.27,1.72±0.26,1.73±0.29),차이균유통계학의의(t검험;P균<0.05);환자조좌측전액협NAA/(Cho+Cr)치(0.64 4±0.13)저우대조조(0.74±0.22),차이유통계학의의(t=2.26,P<0.05).조내비교,환자조화대조조적전액협급구뇌좌、우량측각생화물질대사지표적차이균무통계학의의(t검험;P균>0.05).결론 정신분렬증환자존재전액협급구뇌신경원적공능화(혹)결구이상,정신분렬증환자화정상인뇌부NAA、Cho、Cr가능병불존재측화현상.
Objective To identify the metabolite levels in prefrontal lobe and thalamus in patients with schizophrenia by proton magnetic resonance spectroscopy (1H-MRS). Methods Thirty-eighty schizophrenics and 38 normal controls were involved in this study. A multi-voxel 1H-MRS was given to all the subjects on prefrontal lobe and thalamus within 24 hours they got in hospital. The N-acetylaspartate (NAA), choline-congtaining compounds (Cho), and creatine compounds (Cr) were measured and the ratios of NAA/Cr, Cho/Cr and NAA/( Cho + Cr) were determined Results In left prefrontal lobe and bilateral thalamus, the NAA/Cr ratio in patients demonstrated lower than that in normal controls ( all P <0. 05). In left prefrontal lobe, the NAA/(Cho + Cr) ratio in patients showed lower than that in normal controls (0. 64 ±0. 13 vs. 0. 74±0. 22,t =2. 26, P<0. 05). Both in patients and in normal controls, there were no significant differences in NAA/Cr, Cho/Cr and NAA/(Cho + Cr) between the two sides (all P >0. 05). Conclusious Abnormalities in neuronal function and/or integrity are present in schizophrenics.There is no significantly lateralized asymmetry for metabolite levels such as NAA, Cho and Cr in either the schizophrenics or the controls.
