CAJ | 학술논문

色素上皮衍生因子（pigment epithelium - derived factor，PEDF）作为丝氨酸蛋白酶抑制剂超家族中的非抑制性成员，具有抗血管生成和抗肿瘤特性。趋化因子受体（CC chemokine receptor，CCR）7属趋化因子受体超家族，与肿瘤侵袭、淋巴结转移密切相关。基质金属蛋白酶（ matrix metalloproteinase，MMP）9为MMP 家族成员之一，通过基质降解和促血管生长参与肿瘤发生发展过程。本文就 PEDF、CCR7和 MMP9在食管癌的最新研究进展作一综述。
색소상피연생인자（pigment epithelium - derived factor，PEDF）작위사안산단백매억제제초가족중적비억제성성원，구유항혈관생성화항종류특성。추화인자수체（CC chemokine receptor，CCR）7속추화인자수체초가족，여종류침습、림파결전이밀절상관。기질금속단백매（ matrix metalloproteinase，MMP）9위MMP 가족성원지일，통과기질강해화촉혈관생장삼여종류발생발전과정。본문취 PEDF、CCR7화 MMP9재식관암적최신연구진전작일종술。
As a non - inhibited member of the serine protease inhibitor(serpin)superfamily,Pigment epithelium -derived factor(PEDF)has the antiangiogenic and antitumorigenic activities. CC chemokine receptor(CCR)7 be-longs to the chemokine receptor superfamily,and is closely related to tumour cell invasion and lymphatic metastasis. Matrix metalloproteinase(MMP)9 is a member of Matrix metalloproteinase family,and takes part in the generation and development of the tumor through degrading the matrix and stimulating the growth of blood vessels. This article re-viewed the latest advances in the study on PEDF,CCR7 and MMP9 in esophageal carcinoma.