CAJ | 학술논문

目的：检测 miR -542-5p 在浆液性卵巢癌中的表达，并分析 miR -542-5p 的表达与浆液性卵巢癌临床病理特征之间的关系，探讨其意义。方法：采用实时荧光定量 PCR 技术分析100例浆液性卵巢癌组织及50例正常输卵管伞端组织中 miR -542-5p 的表达。结果：浆液性卵巢癌组织中 miR -542-5p 的表达显著低于正常输卵管伞端组织（P ﹤0.05）。miR -542-5p 的表达与浆液性卵巢癌各临床病理特征之间差异均无统计学意义（P ﹥0.05）。结论：miR -542-5p 可能作为抑癌基因参与了浆液性卵巢癌的发生，对于卵巢癌的早期诊断及治疗具有潜在意义。
목적：검측 miR -542-5p 재장액성란소암중적표체，병분석 miR -542-5p 적표체여장액성란소암림상병리특정지간적관계，탐토기의의。방법：채용실시형광정량 PCR 기술분석100례장액성란소암조직급50례정상수란관산단조직중 miR -542-5p 적표체。결과：장액성란소암조직중 miR -542-5p 적표체현저저우정상수란관산단조직（P ﹤0.05）。miR -542-5p 적표체여장액성란소암각림상병리특정지간차이균무통계학의의（P ﹥0.05）。결론：miR -542-5p 가능작위억암기인삼여료장액성란소암적발생，대우란소암적조기진단급치료구유잠재의의。
To detect the expression of miR - 542 - 5p in serous ovarian cancer,and analyze the corre-lation of its expression with clinicpathological features,investigate the significance in carcinogenesis and development. Methods:Using quantitative real - time PCR to assess the expression of miR - 542 - 5p in 100 serous ovarian cancer tissues and 50 normal fimbriated end of the distal fallopian tissues. Results:The expression of miR - 542 - 5p in se-rous ovarian cancer tissues was significantly lower than in normal fimbriated of the distal fallopian tissues(P ﹤ 0. 05). There was no difference for miR - 542 - 5p expression with clinicopathological features in serous ovarian cancer(P ﹥0. 05). Conclusion:miR - 542 - 5p may participate the origination of serous ovarian cancer as a tumor - suppressor, and it has potential significance for the early diagnosis and treatment of ovarian cancer.