CAJ | 학술논문

目的：探讨介入化疗在高危妊娠滋养细胞肿瘤治疗中的应用。方法：2008年7月至2012年7月，在我院进行介入化疗的高危 GTN 患者21例。末次妊娠的性质来源于葡萄胎者10例，流产后8例，中孕引产后1例，足月产后2例。21例高危 GTN 患者均采用 EMA - EP 介入化疗方案，VP16100mg/ m2+0.9% NS 40ml， d8介入；DDP 80mg/ m2+0.9% NS 100ml，d8介入。介入化疗前后均行妇科检查、彩色多普勒超声检查、胸部 X线或肺部 CT 检查、血β- HCG 水平测定以明确诊断和进行疗效判定。结果：21例患者共行39次动脉插管，其中双侧子宫动脉插管24次，支气管动脉插管8次，左侧卵巢动脉插管2次，肠系膜下动脉插管2次，膀胱上动脉插管2次，阴部内动脉插管1次。介入化疗的有效率为95.2%。结论：介入化疗能提高高危 GTN 患者的化疗效果，降低化疗的耐药问题，有可能缩短治疗疗程，更重要的是可以保留脏器功能。对于高危 GTN 患者，介入化疗提供了新型、高效的方法。
목적：탐토개입화료재고위임신자양세포종류치료중적응용。방법：2008년7월지2012년7월，재아원진행개입화료적고위 GTN 환자21례。말차임신적성질래원우포도태자10례，유산후8례，중잉인산후1례，족월산후2례。21례고위 GTN 환자균채용 EMA - EP 개입화료방안，VP16100mg/ m2+0.9% NS 40ml， d8개입；DDP 80mg/ m2+0.9% NS 100ml，d8개입。개입화료전후균행부과검사、채색다보륵초성검사、흉부 X선혹폐부 CT 검사、혈β- HCG 수평측정이명학진단화진행료효판정。결과：21례환자공행39차동맥삽관，기중쌍측자궁동맥삽관24차，지기관동맥삽관8차，좌측란소동맥삽관2차，장계막하동맥삽관2차，방광상동맥삽관2차，음부내동맥삽관1차。개입화료적유효솔위95.2%。결론：개입화료능제고고위 GTN 환자적화료효과，강저화료적내약문제，유가능축단치료료정，경중요적시가이보류장기공능。대우고위 GTN 환자，개입화료제공료신형、고효적방법。
To study the application of interventional chemotherapy in the high risk gestational tropho-blastic neoplasia. Methods:From 2008 July to 2012 July,there were 21 patients with high risk GTN with intervention-al chemotherapy in Shaanxi Province Tumor Hospital. The last pregnancy properties derived from 10 cases of hydatidi-form mole,8 cases of abortion,pregnancy induced labor in 1 case,2 cases of term pregnancy. 21 cases of high - risk GTN patients were treated with EMA - EP chemotherapy scheme. Determination of before and after interventional chemotherapy underwent gynecological examination,color Doppler ultrasonography,chest X ray or lung CT examina-tion,the blood β - HCG levels were determined to confirm the diagnosis and curative effect. Results:A total of 39 ar-tery intubation,the bilateral uterine artery catheterization of bronchial artery intubation 24 times,8 times,2 times the left ovarian artery,the inferior mesenteric artery intubation 2 times,2 times the bladder artery,internal pudendal artery 1 time. The effective rate was 95. 2% . Conclusion:Intervention chemotherapy can improve the effect of chemotherapy for patients with high risk GTN,reducing the drug resistance of chemotherapy,may shorten the course of treatment, more importantly can preserve organ function. For the high - risk patients with GTN,intervention chemotherapy may be a new efficient method.