CAJ | 학술논문

目的：探讨 MACC1与 c - met 蛋白在子宫内膜癌中的表达及其临床意义。方法：应用免疫组织化学方法检测45例子宫内膜癌组织、38例增生子宫内膜组织、20例正常子宫内膜组织中 MACC1与 c - met 蛋白的表达情况，分析两者在不同子宫内膜中的表达率及其与子宫内膜癌临床病理参数的关系，并分析两指标在子宫内膜癌组织中表达的相关性。结果：MACC1与 c - met 在子宫内膜癌组织中的阳性表达率显著高于增生子宫内膜组织、正常子宫内膜组织（P ﹤0.05）。MACC1与 c - met 在子宫内膜癌组织中的表达与肌层浸润深度、手术病理分期、组织分化级别显著相关，而与年龄、肿瘤大小等无关。MACC1与 c - met 蛋白的表达呈正相关（P ﹤0.05）。结论：MACC1与 c - met 在子宫内膜癌组织中表达增高，肌层浸润较深、手术病理分期越晚、组织分化程度较低者表达率更高，两者与肿瘤的发生、发展、转移关系密切。
목적：탐토 MACC1여 c - met 단백재자궁내막암중적표체급기림상의의。방법：응용면역조직화학방법검측45례자궁내막암조직、38례증생자궁내막조직、20례정상자궁내막조직중 MACC1여 c - met 단백적표체정황，분석량자재불동자궁내막중적표체솔급기여자궁내막암림상병리삼수적관계，병분석량지표재자궁내막암조직중표체적상관성。결과：MACC1여 c - met 재자궁내막암조직중적양성표체솔현저고우증생자궁내막조직、정상자궁내막조직（P ﹤0.05）。MACC1여 c - met 재자궁내막암조직중적표체여기층침윤심도、수술병리분기、조직분화급별현저상관，이여년령、종류대소등무관。MACC1여 c - met 단백적표체정정상관（P ﹤0.05）。결론：MACC1여 c - met 재자궁내막암조직중표체증고，기층침윤교심、수술병리분기월만、조직분화정도교저자표체솔경고，량자여종류적발생、발전、전이관계밀절。
To detect the expression of MACC1 and c - met protein in endometrial carcinoma and study its significance. Methods:Immunohistochemistry assay was used for the detection of MACC1 and c - met protein in 45 endometrial carcinoma cases,38 hyperplasia endometrium cases,20 normal endometrial cases. Results:The positive expression rate of MACC1 and c - met protein in endometrial carcinoma tissue were both significantly higher than those in hyperplasia endometrium tissue and normal endometrial tissue(P ﹤ 0. 05). All of their expressions were relat-ed with myometrial invasion,surgical pathologic stage and tissue differentiation level(P ﹤ 0. 05). While there were no significantly relationship with age and size of the tumor. In addition,the expression of MACC1 and c - met protein were positively correlated with them in endometrial carcinoma(P ﹤ 0. 05). Conclusion:MACC1 and c - met were highly expressed in endometrial carcinoma. Infiltrating deeper at the grass - roots level,the later surgical pathologic stage,tissue differentiation degree lower expression rate higher,both closely related to occurrence,development,and metastasis of tumor.