CAJ | 학술논문

目的：检测 miR -129-1-3p 在浆液性卵巢癌组织与正常输卵管伞端组织中的表达，并分析 miR -129-1-3p 与卵巢浆液性上皮性癌临床病理特征之间的关系。方法：采用实时荧光定量聚合酶链反应（qRT- PCR）定量分析100例浆液性卵巢上皮性癌组织、50例正常输卵管伞端组织中 miR -129-1-3p 的表达，并将检测结果与临床和病理特征资料进行统计学分析。结果：浆液性卵巢癌组织中的 miR -129-1-3p 表达量显著低于正常输卵管伞端组织（P ﹤0.01）。miR -129-1-3p 的表达与 FIGO 分期、患者年龄、病理分化程度、淋巴结转移、血清 CA125值无统计学差异（P ﹥0.05）。结论：miR -129-1-3p 可能作为抑癌因子参与了卵巢上皮性癌的发生发展，对卵巢上皮性癌具有潜在的辅助诊断意义，为寻找卵巢上皮性癌的生物靶向治疗提供理论依据。
목적：검측 miR -129-1-3p 재장액성란소암조직여정상수란관산단조직중적표체，병분석 miR -129-1-3p 여란소장액성상피성암림상병리특정지간적관계。방법：채용실시형광정량취합매련반응（qRT- PCR）정량분석100례장액성란소상피성암조직、50례정상수란관산단조직중 miR -129-1-3p 적표체，병장검측결과여림상화병리특정자료진행통계학분석。결과：장액성란소암조직중적 miR -129-1-3p 표체량현저저우정상수란관산단조직（P ﹤0.01）。miR -129-1-3p 적표체여 FIGO 분기、환자년령、병리분화정도、림파결전이、혈청 CA125치무통계학차이（P ﹥0.05）。결론：miR -129-1-3p 가능작위억암인자삼여료란소상피성암적발생발전，대란소상피성암구유잠재적보조진단의의，위심조란소상피성암적생물파향치료제공이론의거。
To detect the miR - 129 - 1 - 3p expression in the epithelial ovarian cancer and analyze the correlation of its expression with clinicopathonological features. Methods:Quantitative real - time PCR was employed to test the miR - 129 - 1 - 3p expression in 150 specimens(including 100 malignant serous epithelial ovarian cancer and 50 the normal fimbriated end of the distal fallopian tube). The relevance between the miR - 129 - 1 - 3p expres-sion and the pathoclinical characteristics was assessed. Results:The expression of miR - 129 - 1 - 3p was significant-ly down - regulated in patients with serous ovarian cancer compared to normal controls(P ﹤ 0. 01). Low expression of miR - 129 - 1 - 3p was not related to FIGO stage,age,pathologic differentiation,lymph node metastasis,and serum level of CA125(P ﹥ 0. 05). Conclusion:miR - 129 - 1 - 3p may participate the origination and progression of serous epithelial ovarian cancer as a tumor - supressor. It may represent potential indicator in the auxiliary of epithelial se-rous ovarian cancer and provide the theory basis to the biological targeted therapy of epithelial ovarian cancer.