CAJ | 학술논문

目的：评价替吉奥联合奥沙利铂治疗晚期胃癌的近期疗效及毒副反应。方法：70例晚期胃癌患者，随机分成对照组与治疗组，每组各35例。治疗组为替吉奥联合奥沙利铂方案，对照组采用奥沙利铂联合亚叶酸钙和5-氟尿嘧啶治疗，2个周期后评价疗效，随访疾病进展时间和总生存期。结果：治疗组总有效率（34.2%）高于对照组总有效率（22.9%），具有统计学意义（P ﹤0.05）。无疾病进展时间和总生存期治疗组分别为6.8个月和14.0个月，对照组分别为6.6个月和13.5个月，无统计学差异（P ﹥0.05）。治疗组不良反应发生率明显较对照组低（P ﹤0.05）。结论：替吉奥胶囊联合奥沙利铂方案治疗晚期胃癌的疗效可靠，毒副作用较轻，不良反应可以耐受，特别适用于年龄较大、一般状态较差的患者。
목적：평개체길오연합오사리박치료만기위암적근기료효급독부반응。방법：70례만기위암환자，수궤분성대조조여치료조，매조각35례。치료조위체길오연합오사리박방안，대조조채용오사리박연합아협산개화5-불뇨밀정치료，2개주기후평개료효，수방질병진전시간화총생존기。결과：치료조총유효솔（34.2%）고우대조조총유효솔（22.9%），구유통계학의의（P ﹤0.05）。무질병진전시간화총생존기치료조분별위6.8개월화14.0개월，대조조분별위6.6개월화13.5개월，무통계학차이（P ﹥0.05）。치료조불량반응발생솔명현교대조조저（P ﹤0.05）。결론：체길오효낭연합오사리박방안치료만기위암적료효가고，독부작용교경，불량반응가이내수，특별괄용우년령교대、일반상태교차적환자。
To explore the efficacy of oxalipltin combined with S - 1 capsule on advanced gastric cancer (AGC)and toxicity. Methods:All the 70 patients with AGC were divided into two groups. The treatment groups:35 patients received S - 1 capsule and oxaliplatin;the control group:35 patients received oxaliplatin and 5 - FU and CF. All patients received 2 cycles at least. The time to progress and overall survival were observed. Results:The overall response rate(34. 2% )in the treatment group was higher than in the control group(22. 9% ). The median time to progress were 6. 8 and 6. 6 months,and the median overall survival(OS)were 14. 0 and 13. 5 months(P ﹥ 0. 05). The overall response rate was significantly difference between two groups(P ﹤ 0. 05). Conclusion:S - 1 capsule com-bined with oxaliplatin is effective and light side effect in the treatment of patients with AGC,especially for old pa-tients.