CAJ | 학술논문

目的：探讨 Plk1和 p27在甲状腺乳头状癌中的表达及与甲状腺乳头状癌预后的关系。方法：采用免疫组织化学技术检测 Plk1和 p27在甲状腺乳头状癌中的表达情况。结果：甲状腺乳头状癌中 Plk1的阳性表达率明显高于正常甲状腺组织（P ﹤0.05）。Plk1在微灶癌（直径≤1cm）中的阳性表达率明显高于在癌灶直径﹥1cm 的甲状腺乳头状癌（P ﹤0.05）。甲状腺乳头状癌中 p27阳性表达率（44.12%）明显低于正常甲状腺组织（80.00%，P ﹤0.05）。Plk1和 p27表达与包膜浸润、淋巴结转移情况相关。结论：Plk1在早期甲状腺乳头状癌的发生、发展中起重要作用，联合检测 Plk1和 p27有助于甲状腺乳头状癌的诊断及预后评估。
목적：탐토 Plk1화 p27재갑상선유두상암중적표체급여갑상선유두상암예후적관계。방법：채용면역조직화학기술검측 Plk1화 p27재갑상선유두상암중적표체정황。결과：갑상선유두상암중 Plk1적양성표체솔명현고우정상갑상선조직（P ﹤0.05）。Plk1재미조암（직경≤1cm）중적양성표체솔명현고우재암조직경﹥1cm 적갑상선유두상암（P ﹤0.05）。갑상선유두상암중 p27양성표체솔（44.12%）명현저우정상갑상선조직（80.00%，P ﹤0.05）。Plk1화 p27표체여포막침윤、림파결전이정황상관。결론：Plk1재조기갑상선유두상암적발생、발전중기중요작용，연합검측 Plk1화 p27유조우갑상선유두상암적진단급예후평고。
To identify the expression of Plk1 and p27 and to discuss its relationship with prognosis in thyroid papillary carcinoma. Methods:Plk1 protein expression level in thyroid papillary carcinomas was detected by immunohistochemistry method. Results:The positive expression rate of Plk1 in thyroid papillary carcinoma was signifi-cantly higher than that in normal thyroid(P ﹤ 0. 05). The expression in thyroid papillary microcarcinoma(≤1cm) tissues was significantly higher than that in larger thyroid papillary carcinoma( ﹥ 1cm)tissues(P ﹤ 0. 05). The posi-tive expression rate of p27 in the thyroid papillary carcinoma 44. 12% was significantly lower than that in normal thy-roid 80. 00%(P ﹤ 0. 05). The positive expression of Plkl and p27 was correlated with lymph node metastasis,envelop invasion(P ﹤ 0. 05). Conclusion:Plk1 plays a constitutive role in the carcinogenesis and progression in thyroid pa-pillary carcinoma especially in the early phase,markedly correlated with the expression of Plk1 and p27 may be a powerful and aid in evaluating prognosis and infiltrative capability of thyroid papillary carcinoma.