CAJ | 학술논문

目的：探讨 DEK 蛋白表达与星形细胞肿瘤发生、发展的关系。方法：免疫印迹杂交法检测 DEK 蛋白在星形细胞肿瘤组织及正常脑组织中的表达水平。结果：DEK 蛋白表达阳性率在肿瘤组织中为93.75%， DEK 蛋白相对含量分别为：低级别肿瘤组织0.55±0.11，高级别肿瘤组织0.85±0.07；DEK 蛋白在肿瘤组织中的表达显著高于其在正常脑组织中的表达（P ﹤0.05）。结论：DEK 蛋白表达与星形细胞肿瘤的发生、发展呈显著正相关，是评估星形细胞肿瘤恶性生物学行为的可靠指标。DEK 作为凋亡抑制基因为星形细胞肿瘤的治疗提供了一个新靶点。
목적：탐토 DEK 단백표체여성형세포종류발생、발전적관계。방법：면역인적잡교법검측 DEK 단백재성형세포종류조직급정상뇌조직중적표체수평。결과：DEK 단백표체양성솔재종류조직중위93.75%， DEK 단백상대함량분별위：저급별종류조직0.55±0.11，고급별종류조직0.85±0.07；DEK 단백재종류조직중적표체현저고우기재정상뇌조직중적표체（P ﹤0.05）。결론：DEK 단백표체여성형세포종류적발생、발전정현저정상관，시평고성형세포종류악성생물학행위적가고지표。DEK 작위조망억제기인위성형세포종류적치료제공료일개신파점。
To investigate the relationship between DEK protein and carcinogensis,development of as-trocytic tumors. Methods:Western blot technique was adopted to examine the levels of expression of DEK protein in astrocytic tumours tissues and brain tissues. Results:The rate of positive expression of DEK protein was:Astrocytic tumours(93. 75% ),brain tissues(0. 00% ). The relative content of DEK was:Low astrocytoma(0. 55 ± 0. 11), hight astrocytoma(0. 85 ± 0. 07). The expression of DEK protein in astrocytoma was significantly higher than in brain tissues(P ﹤ 0. 05). Conclusion:The expression of DEK protein are strong correlated with carcinogensis and develop-ment of astrocytic tumors,and it is not only an effective marker in diagnosis of astrocytic tumors but also a new target for astrocytic tumors therapy.