现代肿瘤医学
現代腫瘤醫學
현대종류의학
JOURNAL OF MODERN ONCOLOGY
2014年
8期
1795-1797
,共3页
钟俐强%杨斯皓%雷开键%贾钰铭
鐘俐彊%楊斯皓%雷開鍵%賈鈺銘
종리강%양사호%뢰개건%가옥명
重组人粒细胞集落刺激因子%康复新液%放射性口腔炎
重組人粒細胞集落刺激因子%康複新液%放射性口腔炎
중조인립세포집락자격인자%강복신액%방사성구강염
recombinant human granulocyte colony -stimulating factor%Kangfuxin%radiation - induced oral mucositis
目的：观察康复新液联合 rhG - CSF（重组人粒细胞集落刺激因子）局部应用对放射性口腔炎的防治效果。方法：将46例经病理确诊的头颈部恶性肿瘤患者随机分为两组，实验组（23例）采用康复新液联合rhG - CSF 稀释后含漱，对照组（23例）采用 rhG - CSF 稀释后含漱，两组均采用常规分割方式放疗。采用全美放射肿瘤治疗协作组（RTOG）急性放射性黏膜炎的分级标准，观察放射性口腔炎的发生时间、发生率及严重程度。结果：实验组与对照组放射性口腔炎平均发生时间分别为（28.57±1.93）d 及（19.57±1.95）d，P﹤0.001。放射性口腔炎总发生率分别为65.22%及91.30%，P =0.032。2级以上放射性口腔黏膜损伤发生率分别为17.39%及47.83%，P =0.028。结论：康复新液联合 rhG - CSF 能够延迟放射性口腔炎出现时间，降低放射性口腔的发生率，并减轻其损伤程度。
目的：觀察康複新液聯閤 rhG - CSF（重組人粒細胞集落刺激因子）跼部應用對放射性口腔炎的防治效果。方法：將46例經病理確診的頭頸部噁性腫瘤患者隨機分為兩組，實驗組（23例）採用康複新液聯閤rhG - CSF 稀釋後含漱，對照組（23例）採用 rhG - CSF 稀釋後含漱，兩組均採用常規分割方式放療。採用全美放射腫瘤治療協作組（RTOG）急性放射性黏膜炎的分級標準，觀察放射性口腔炎的髮生時間、髮生率及嚴重程度。結果：實驗組與對照組放射性口腔炎平均髮生時間分彆為（28.57±1.93）d 及（19.57±1.95）d，P﹤0.001。放射性口腔炎總髮生率分彆為65.22%及91.30%，P =0.032。2級以上放射性口腔黏膜損傷髮生率分彆為17.39%及47.83%，P =0.028。結論：康複新液聯閤 rhG - CSF 能夠延遲放射性口腔炎齣現時間，降低放射性口腔的髮生率，併減輕其損傷程度。
목적：관찰강복신액연합 rhG - CSF（중조인립세포집락자격인자）국부응용대방사성구강염적방치효과。방법：장46례경병리학진적두경부악성종류환자수궤분위량조，실험조（23례）채용강복신액연합rhG - CSF 희석후함수，대조조（23례）채용 rhG - CSF 희석후함수，량조균채용상규분할방식방료。채용전미방사종류치료협작조（RTOG）급성방사성점막염적분급표준，관찰방사성구강염적발생시간、발생솔급엄중정도。결과：실험조여대조조방사성구강염평균발생시간분별위（28.57±1.93）d 급（19.57±1.95）d，P﹤0.001。방사성구강염총발생솔분별위65.22%급91.30%，P =0.032。2급이상방사성구강점막손상발생솔분별위17.39%급47.83%，P =0.028。결론：강복신액연합 rhG - CSF 능구연지방사성구강염출현시간，강저방사성구강적발생솔，병감경기손상정도。
To observe the prevention and cure effect of combine Kangfuxin with rhG - CSF(recombi-nant human granulocyte colony - stimulating factor)on radiation - induced oral mucositis. Methods:All 46 cases of head and neck malignant tumor patients who received radiotherapy were divided into two groups:The research group,23 cases,use the mouthwash contain Kangfuxin and rhG - CSF;the control group,23 cases,ues the mouthwash just contain rhG - CSF. Both the two groups were adopted conventional fractionated radiotherapy. The evaluation of radia-tion oral mucositis was done according to the systems proposed by RTOG. The occurrence time,incidence rate and the degree of injury were observed. Results:In research group and control group the occurrence time of radiation - in-duced oral mucositis were(28. 57 ± 1. 93)days and(19. 57 ± 1. 95)days respectively,the total incidences of radia-tion - induced oral mucositis was 65. 22% and 91. 30% respectively,the incidences of above grade 2 radiation - in-duced oral mucositis was 17. 39% and 47. 83% . All the differences were significant(P ﹤ 0. 05). Conclusion:Kang-fuxin combined with rhG - CSF could delay the occurrence time,reduce the incidence and degrade the degree of inju-ry on radiation - induced oral mucositis.
