临床医药实践
臨床醫藥實踐
림상의약실천
PROCEEDING OF CLINICAL MEDICINE
2014年
8期
581-582
,共2页
急性脑梗死%高同型半胱氨酸血症%神经功能缺损评分
急性腦梗死%高同型半胱氨痠血癥%神經功能缺損評分
급성뇌경사%고동형반광안산혈증%신경공능결손평분
acutecerebralinfarction%hyperhomocysteinemia%neurologicaldeficitscores
目的：探讨急性脑梗死与高同型半胱氨酸（ Hcy）血症的关系。方法：选取150例合并高血压的急性脑梗死住院患者为观察组，另选取同期门诊就诊的未发生脑梗死的高血压患者150例为对照组。两组患者分别进行空腹Hcy水平的测定，并进行比较。根据入院24 h内Hcy是否升高，将150例脑梗死住院患者分为高Hcy组（88例）和正常Hcy组（62例），两组患者分别于住院时及发病4周时进行神经功能缺损评分（ NIHSS评分）。结果：高同型半胱氨酸血症在观察组中占58.7%，对照组中占15.3%（P﹤0.01）；空腹Hcy浓度观察组为（31.26±4.61）μmol/L，对照组为（15.92±3.43）μmol/L，差异有统计学意义（ P﹤0.01）。高Hcy组与正常Hcy组入院时NIHSS评分比较，差异无统计学意义（P﹥0.05）。两组于发病4周时进行NIHSS评分，高Hcy组评分高于正常Hcy组（P﹤0.01）。结论：高Hcy血症是脑梗死发生的重要危险因素，高Hcy的脑梗死患者预后较差。积极干预高Hcy血症有助于防止脑梗死的发生或改善脑梗死患者的预后。
目的：探討急性腦梗死與高同型半胱氨痠（ Hcy）血癥的關繫。方法：選取150例閤併高血壓的急性腦梗死住院患者為觀察組，另選取同期門診就診的未髮生腦梗死的高血壓患者150例為對照組。兩組患者分彆進行空腹Hcy水平的測定，併進行比較。根據入院24 h內Hcy是否升高，將150例腦梗死住院患者分為高Hcy組（88例）和正常Hcy組（62例），兩組患者分彆于住院時及髮病4週時進行神經功能缺損評分（ NIHSS評分）。結果：高同型半胱氨痠血癥在觀察組中佔58.7%，對照組中佔15.3%（P﹤0.01）；空腹Hcy濃度觀察組為（31.26±4.61）μmol/L，對照組為（15.92±3.43）μmol/L，差異有統計學意義（ P﹤0.01）。高Hcy組與正常Hcy組入院時NIHSS評分比較，差異無統計學意義（P﹥0.05）。兩組于髮病4週時進行NIHSS評分，高Hcy組評分高于正常Hcy組（P﹤0.01）。結論：高Hcy血癥是腦梗死髮生的重要危險因素，高Hcy的腦梗死患者預後較差。積極榦預高Hcy血癥有助于防止腦梗死的髮生或改善腦梗死患者的預後。
목적：탐토급성뇌경사여고동형반광안산（ Hcy）혈증적관계。방법：선취150례합병고혈압적급성뇌경사주원환자위관찰조，령선취동기문진취진적미발생뇌경사적고혈압환자150례위대조조。량조환자분별진행공복Hcy수평적측정，병진행비교。근거입원24 h내Hcy시부승고，장150례뇌경사주원환자분위고Hcy조（88례）화정상Hcy조（62례），량조환자분별우주원시급발병4주시진행신경공능결손평분（ NIHSS평분）。결과：고동형반광안산혈증재관찰조중점58.7%，대조조중점15.3%（P﹤0.01）；공복Hcy농도관찰조위（31.26±4.61）μmol/L，대조조위（15.92±3.43）μmol/L，차이유통계학의의（ P﹤0.01）。고Hcy조여정상Hcy조입원시NIHSS평분비교，차이무통계학의의（P﹥0.05）。량조우발병4주시진행NIHSS평분，고Hcy조평분고우정상Hcy조（P﹤0.01）。결론：고Hcy혈증시뇌경사발생적중요위험인소，고Hcy적뇌경사환자예후교차。적겁간예고Hcy혈증유조우방지뇌경사적발생혹개선뇌경사환자적예후。
Tostudytherelevancebetweenhyperhomocysteinemia(Hcy)andacutecerebralinfarction.Meth-ods:One hundred and fifty inpatients with acute cerebral infarction were selected as the observation group and 150 clinical pa-tients with hypertension contemporaneous were selected as the control group. Patients of the two group all had fasting Hcy test and their results were compared. To divide 150 inpatients with acute cerebral infarction into high Hcy group(88 cases)and normal Hcy group(62 cases). Neurological deficit scores(NIHSS)of the two group were detected when the patient was admit-ted and four weeks after onset. Results:Hyperhomocysteinemia was 58. 7% in the observation group while 15. 3% in the con-trolgroup . Fasting Hcy of the observation group was( 3 1 . 2 6 ± 4 . 6 1 )μmol/ L . while that of the control group was( 1 5 . 9 2 ± 3. 43)μmol/L(P﹤0. 01). NIHSS had no statistical significance when patients were admitted(P﹥0. 05). But four weeks af-ter onset,NIHSS of the high Hcy group was higher than the control group(P﹤0. 01). Conclusion:Hyperhomocysteinemia is important risk factor of acute cerebral Infarction. The patients with acute cerebral Infarction show the poor prognosis while they have higher Hcy. Active intervention to hyperhomocysteinemia will help to prevent acute cerebral Infarction or improve progno-sis of patients with acute cerebral Infarction.
