临床医药实践
臨床醫藥實踐
림상의약실천
PROCEEDING OF CLINICAL MEDICINE
2014年
8期
576-577,578
,共3页
幽门螺旋杆菌%根除率%疗效观察
幽門螺鏇桿菌%根除率%療效觀察
유문라선간균%근제솔%료효관찰
helicobacterpylori%eradicationrate%effectobservation
目的:对比盐酸小檗碱片联合四联疗法和四联疗法根除幽门螺杆菌( Hp)方案的临床效果,为临床治疗方案的选择提供参考。方法:将160例幽门螺杆菌阳性消化性溃疡患者随机分为两组。A组:口服埃索美拉唑(20 mg)+阿莫西林(1.0 g)+枸橼酸铋钾(220 mg)+克拉霉素(0.5 g),每日2次,服用10 d。B组:口服埃索美拉唑(20 mg)+枸橼酸铋钾(220mg)+阿莫西林(1.0g)+克拉霉素(0.5g),每日2次,盐酸小檗碱片300mg,每日3次,服用10 d。观察记录Hp根除情况及不良反应。结果:两组Hp根除率分别为81.23%和87.50%,差异有统计学意义( P﹤0.05)。两组不良反应率比较,差异无统计学意义( P﹤0.05)。结论:盐酸小檗碱片联合铋剂四联组不良反应未明显增加,根除率更高,是较理想的治疗方案。
目的:對比鹽痠小檗堿片聯閤四聯療法和四聯療法根除幽門螺桿菌( Hp)方案的臨床效果,為臨床治療方案的選擇提供參攷。方法:將160例幽門螺桿菌暘性消化性潰瘍患者隨機分為兩組。A組:口服埃索美拉唑(20 mg)+阿莫西林(1.0 g)+枸櫞痠鉍鉀(220 mg)+剋拉黴素(0.5 g),每日2次,服用10 d。B組:口服埃索美拉唑(20 mg)+枸櫞痠鉍鉀(220mg)+阿莫西林(1.0g)+剋拉黴素(0.5g),每日2次,鹽痠小檗堿片300mg,每日3次,服用10 d。觀察記錄Hp根除情況及不良反應。結果:兩組Hp根除率分彆為81.23%和87.50%,差異有統計學意義( P﹤0.05)。兩組不良反應率比較,差異無統計學意義( P﹤0.05)。結論:鹽痠小檗堿片聯閤鉍劑四聯組不良反應未明顯增加,根除率更高,是較理想的治療方案。
목적:대비염산소벽감편연합사련요법화사련요법근제유문라간균( Hp)방안적림상효과,위림상치료방안적선택제공삼고。방법:장160례유문라간균양성소화성궤양환자수궤분위량조。A조:구복애색미랍서(20 mg)+아막서림(1.0 g)+구연산필갑(220 mg)+극랍매소(0.5 g),매일2차,복용10 d。B조:구복애색미랍서(20 mg)+구연산필갑(220mg)+아막서림(1.0g)+극랍매소(0.5g),매일2차,염산소벽감편300mg,매일3차,복용10 d。관찰기록Hp근제정황급불량반응。결과:량조Hp근제솔분별위81.23%화87.50%,차이유통계학의의( P﹤0.05)。량조불량반응솔비교,차이무통계학의의( P﹤0.05)。결론:염산소벽감편연합필제사련조불량반응미명현증가,근제솔경고,시교이상적치료방안。
Tocomparetheclinicaleffectofberberinehydrochloridetabletscombinedquadruplechemotherapy for the eradication of helicobacter pylori( Hp),provide reference for the choice of treatment. Methods:A total of 160 patients with helicobacter pylori positive peptic ulcer disease were dvided into two groups . The group A :take orally esomeprazole (20 mg)+amoxicillin(1. 0 g)+colloidal bismuth subcitrate(220 mg)+ clarithromycin(0. 5 g),2 times per day,for ten days. The group B:take orally esomeprazole(20 mg)+colloidal bismuth subcitrate(220 mg)+amoxicillin(1. 0 g)+clarithro-mycin(0. 5 g),2 times per day,+berberine hydrochloride tablets(300 mg),3 times per day,for ten days. To observe and re-cord the eradication and adverse reactions of Hp. Results:The total eradication rate of HP of the group A were 81. 23%. The total eradication rate of HP of the group B were 87. 50%,siginificantly higher than the group A,the difference was statistically siginifiant(P﹤0. 05). The incidence adverse reactions of group B and group A were simler. The difference was not statistically siginificant(P﹥0. 05). Conclusion:Bismuth agent four transmitte adverse reactions did not significantly increased,the eradica-tion rate is higher,is the ideal reatment.