CAJ | 학술논문

利用静电纺丝技术制备了负载亲水性药物阿霉素( DOX)以及疏水性药物喜树碱( CPT)的复合纳米纤维。先用巯基封端的普朗尼克(F127)修饰纳米氧化锌(FZnO)，再将FZnO负载盐酸阿霉素(DOX@FZnO)，最后将DOX@FZnO与CPT一起纺入聚乳酸-乙醇酸( PLGA)纤维中。体外药物释放结果表明，复合纳米纤维能够减小亲水性药物的突释，减缓药物释放速率，延长药物释放时间。体外细胞活性结果表明，双载药复合纤维比单载药复合纤维具有更强的细胞毒性，能够有效抑制癌细胞生长。
이용정전방사기술제비료부재친수성약물아매소( DOX)이급소수성약물희수감( CPT)적복합납미섬유。선용구기봉단적보랑니극(F127)수식납미양화자(FZnO)，재장FZnO부재염산아매소(DOX@FZnO)，최후장DOX@FZnO여CPT일기방입취유산-을순산( PLGA)섬유중。체외약물석방결과표명，복합납미섬유능구감소친수성약물적돌석，감완약물석방속솔，연장약물석방시간。체외세포활성결과표명，쌍재약복합섬유비단재약복합섬유구유경강적세포독성，능구유효억제암세포생장。
A novel poly( lactic-co-glycolic acid) ( PLGA)/ZnO electrospun composite fibers encapsulated with both hydrophilic drug(doxorubicin hydrochloride, DOX) and hydrophobic drug(camptothecin, CPT) were fabricated via electrospinning method. Primarily, the ZnO was decorat with F127 and then used to encapsulate DOX. Finally, the DOX-loaded ZnO( DOX@ZnO) and CPT were mixed with PLGA solution to fabricate elec-trospun hybrid nanofibers. The in vitro release results demonstrated the composite fibers decreased the burst release and increased the time of release, which showed a long-term and sustained release. The cell cytotoxici-ty test demonstated that the composite nanofiber with two drugs showed stronger antitumor efficacy against HepG-2 cells than the nanofiber with single drug. Thus, the composite nanofibers with two anticancer drugs could be a versatile drug delivery system as local implantable scaffolds for potential postsurgical cancer treat-ment.