中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2014年
2期
214-216
,共3页
前列腺素E1%慢性肾功能衰竭%尿蛋白
前列腺素E1%慢性腎功能衰竭%尿蛋白
전렬선소E1%만성신공능쇠갈%뇨단백
Prostaglandin E1 (PGE1)%Chronic renal failure%Proteinuria
目的 观察前列腺素E1(PGE1)在慢性肾衰竭(CKD 2 ～4期)治疗中的临床应用效果.方法 选取CKD 2 ～4期患者128例,以随机数字表法分为观察组与对照组,每组各64例.对照组给予常规药物治疗,观察组在对照组的基础上增加PGE1,两组均治疗3个月.比较治疗前后的肾功能指标、治疗后临床疗效以及不良反应.结果 治疗前两组患者肾功能指标比较,差异均无统计学意义(t=0.27～0.95,P＞0.05)；治疗后,观察组与对照组24h尿蛋白定量(t=3.41,P＜0.05)、内生肌酐清除率(t=4.04,P＜0.05)、血清肌酐值(t =4.15,P＜0.05)、血清尿素氮(t=3.92,P＜0.05)指标比较,差异均具有统计学意义.观察组与对照组总有效率分别为84.37％、57.81％,差异有统计学意义(x2=5.63,P＜0.05).观察组未见不良反应.结论 在目前尚缺乏特别有效治疗方法的情况下,前列腺素E1的应用可能在改善患者尿蛋白及肾功能方面起到一定的积极作用.
目的 觀察前列腺素E1(PGE1)在慢性腎衰竭(CKD 2 ～4期)治療中的臨床應用效果.方法 選取CKD 2 ～4期患者128例,以隨機數字錶法分為觀察組與對照組,每組各64例.對照組給予常規藥物治療,觀察組在對照組的基礎上增加PGE1,兩組均治療3箇月.比較治療前後的腎功能指標、治療後臨床療效以及不良反應.結果 治療前兩組患者腎功能指標比較,差異均無統計學意義(t=0.27～0.95,P＞0.05)；治療後,觀察組與對照組24h尿蛋白定量(t=3.41,P＜0.05)、內生肌酐清除率(t=4.04,P＜0.05)、血清肌酐值(t =4.15,P＜0.05)、血清尿素氮(t=3.92,P＜0.05)指標比較,差異均具有統計學意義.觀察組與對照組總有效率分彆為84.37％、57.81％,差異有統計學意義(x2=5.63,P＜0.05).觀察組未見不良反應.結論 在目前尚缺乏特彆有效治療方法的情況下,前列腺素E1的應用可能在改善患者尿蛋白及腎功能方麵起到一定的積極作用.
목적 관찰전렬선소E1(PGE1)재만성신쇠갈(CKD 2 ～4기)치료중적림상응용효과.방법 선취CKD 2 ～4기환자128례,이수궤수자표법분위관찰조여대조조,매조각64례.대조조급여상규약물치료,관찰조재대조조적기출상증가PGE1,량조균치료3개월.비교치료전후적신공능지표、치료후림상료효이급불량반응.결과 치료전량조환자신공능지표비교,차이균무통계학의의(t=0.27～0.95,P＞0.05)；치료후,관찰조여대조조24h뇨단백정량(t=3.41,P＜0.05)、내생기항청제솔(t=4.04,P＜0.05)、혈청기항치(t =4.15,P＜0.05)、혈청뇨소담(t=3.92,P＜0.05)지표비교,차이균구유통계학의의.관찰조여대조조총유효솔분별위84.37％、57.81％,차이유통계학의의(x2=5.63,P＜0.05).관찰조미견불량반응.결론 재목전상결핍특별유효치료방법적정황하,전렬선소E1적응용가능재개선환자뇨단백급신공능방면기도일정적적겁작용.
Objective To investigate the clinical effects of prostaglandin E1 (PGE1) in the treatment ot chronic renal failure in the 2nd ～ 4th period.Methods 128 patients with CKDs at stage 2 to 4 were selected and randomly divided into the observation group and control group,64 cases in each group.Patients in control group were given routine drug treatment,and patients in observation group were given PGE1 on the basis of the control group.They all treated for 3 months.Renal function indicators before and after treatment,curative effect and adverse reaction were compared.Results There were no statistical differences in renal function indicators before treatment in two groups (t =0.27 ～ 0.95,P ＞ 0.05).After treatment,the 24 hours urinary protein (t =3.41,P ＜ 0.05),creatinine clearance rate (t =4.04,P ＜ 0.05),serum creatinine (t =4.15,P ＜ 0.05),serum urea nitrogen (t =3.92,P ＜ 0.05) between the two groups had statistical differences.Total effective rate of the observation group was 84.37％,which was significantly higher than 57.81％ of the control group (x2 =5.63,P ＜ 0.05).There was no adverse reaction observed in observation group.Conclusion PGE1 might improve patients' proteinuria and renal function in the current situation of lacking effective treatment.
