动物营养学报
動物營養學報
동물영양학보
ACTA ZOONUTRIMENTA SINICA
2014年
8期
2071-2076
,共6页
蔡杰%唐志如%邓欢%孙志洪%赖星
蔡傑%唐誌如%鄧歡%孫誌洪%賴星
채걸%당지여%산환%손지홍%뢰성
肠道黏膜%抗菌肽%防御素%肠道微生物
腸道黏膜%抗菌肽%防禦素%腸道微生物
장도점막%항균태%방어소%장도미생물
intestinal mucosa%antimicrobial peptides%defensin%intestinal microbiota
肠道微生物与宿主形成共生关系,在维持机体健康的同时,也能对机体造成伤害。肠道抗菌肽是一类对抗外源性病原体致病作用的防御性肽类活性物质,由肠道细胞合成或被分泌到肠道,包括防御素( defensins)、cathelicidins(如 LL-37)、C 型凝集素[如再生胰岛衍生蛋白( REG)家族]、核糖核酸酶( RNases)和S100蛋白(如钙卫蛋白),参与维持动物肠道微生物区系的平衡。本文综述了动物肠道黏膜抗菌肽维持微生物平衡的作用及其机制。
腸道微生物與宿主形成共生關繫,在維持機體健康的同時,也能對機體造成傷害。腸道抗菌肽是一類對抗外源性病原體緻病作用的防禦性肽類活性物質,由腸道細胞閤成或被分泌到腸道,包括防禦素( defensins)、cathelicidins(如 LL-37)、C 型凝集素[如再生胰島衍生蛋白( REG)傢族]、覈糖覈痠酶( RNases)和S100蛋白(如鈣衛蛋白),參與維持動物腸道微生物區繫的平衡。本文綜述瞭動物腸道黏膜抗菌肽維持微生物平衡的作用及其機製。
장도미생물여숙주형성공생관계,재유지궤체건강적동시,야능대궤체조성상해。장도항균태시일류대항외원성병원체치병작용적방어성태류활성물질,유장도세포합성혹피분비도장도,포괄방어소( defensins)、cathelicidins(여 LL-37)、C 형응집소[여재생이도연생단백( REG)가족]、핵당핵산매( RNases)화S100단백(여개위단백),삼여유지동물장도미생물구계적평형。본문종술료동물장도점막항균태유지미생물평형적작용급기궤제。
The gut microbiota form a symbiotic relationship in human and animals,which keep the gut and the host healthy as well as cause potential damage. Antimicrobial peptides of intestinal mucosa synthesized or secre-ted by intestinal cells are a kind of defensive peptides against the pathogenicity of exogenous pathogens. The an-timicrobial peptides of intestinal mucosa,including defensins,cathelicidins( e. g. LL-37 ),C-type lectins ( such as the regenerating islet-derived protein family),ribonucleases( RNases)and S100 proteins( e. g. cal-protectin),are involved in the maintenance of animal intestinal microflora balance. This paper reviewed the effect and mechanism of the animal intestinal mucosal antimicrobial peptides in maintaining microbial flora balance.