CAJ | 학술논문

目的：观察电针对功能性便秘（functional constipation ，FC ）患者自主排便次数、大便性状、焦虑抑郁和胃肠蠕动的影响，探讨电针治疗 FC 的疗效。方法将符合罗马Ⅲ标准的 FC 患者按2砄1的比例，随机分为电针组和药物组。电针组取双侧曲池、上巨虚穴，治疗4周，前两周每周治疗5次，后两周每周治疗3次；药物组口服枸橼酸莫沙必利，每次5 mg ，每天3次，连续服药4周。对两组每周自主排便次数、正常性状大便比例、焦虑自评量表（SAS）、抑郁自评量表（SDS）、胃泌素（GAS）、生长抑素（SST）进行评估。结果对比基线期，电针和药物均能增加自主排便次数（P＜0.01），改善大便性状（P＜0.01）；电针组SAS、SDS评分（P＜0.01）和血清 SST 水平（P＜0.05）显著下降，血清 GAS 水平显著上升（P＜0.01）；药物组 SAS、SDS 评分和血清 SST 水平无显著变化，血清 GAS 水平显著上升（P＜0.01）。结论电针治疗可增加 FC 患者的自主排便次数，改善大便性状，降低焦虑和抑郁状况及血清SST 水平，提高血清GAS水平，从而有效治疗 FC。
목적：관찰전침대공능성편비（functional constipation ，FC ）환자자주배편차수、대편성상、초필억욱화위장연동적영향，탐토전침치료 FC 적료효。방법장부합라마Ⅲ표준적 FC 환자안2결1적비례，수궤분위전침조화약물조。전침조취쌍측곡지、상거허혈，치료4주，전량주매주치료5차，후량주매주치료3차；약물조구복구연산막사필리，매차5 mg ，매천3차，련속복약4주。대량조매주자주배편차수、정상성상대편비례、초필자평량표（SAS）、억욱자평량표（SDS）、위비소（GAS）、생장억소（SST）진행평고。결과대비기선기，전침화약물균능증가자주배편차수（P＜0.01），개선대편성상（P＜0.01）；전침조SAS、SDS평분（P＜0.01）화혈청 SST 수평（P＜0.05）현저하강，혈청 GAS 수평현저상승（P＜0.01）；약물조 SAS、SDS 평분화혈청 SST 수평무현저변화，혈청 GAS 수평현저상승（P＜0.01）。결론전침치료가증가 FC 환자적자주배편차수，개선대편성상，강저초필화억욱상황급혈청SST 수평，제고혈청GAS수평，종이유효치료 FC。
Objective To observe the impact of electro-acupuncture(EA )stimulation on stool frequency ,stool consistency ,anxiety and depression ,and gastrointestinal motility in patients with functional constipation (FC) ,and to explore the therapeutic effects of EA for FC.Methods FC patients who meet Rome Ⅲ criteria were randomly assigned to EA group and medicine group in 2:1 ratio.In EA group ,patients were treated with EA at Quchi (LI11)and Shangjuxu(ST37)bilaterally for 4 weeks ,5 times a week in the first 2 weeks and 3 times a week in the last 2 weeks.In medicine group ,5 mg mosapride citrate was administered orally 3 times a day for 4 weeks.Stool frequency ,stool consistency ,self-rating anxiety scale(SAS) ,self-rating depression scale(SDS) ,serum levels of gas-trin(GAS)and somatostatin(SST )were evaluated.Results Compared with the baseline ,stool frequency per week and the percentage of normal stools per week were both improved significantly in two groups (P<0.01).In EA group ,the scores of SAS and SDS (P<0.01)and the serum level of SST (P<0.05)decreased significantly ,the ser-um level of GAS increased significantly (P< 0.01).In medicine group ,the scores of SAS and SDS and the serum level of SST did not change significantly ,while the serum level of GAS increased significantly ( P<0.01 ).Conclusion EA therapy can increase stool frequency ,improve stool consistency ,decrease the patient’s anxiety and depression and the serum level of SST ,and increase the serum level of GAS effectively.EA treatment is effec-tive for FC patients.