CAJ | 학술논문

双水相萃取技术作为一种新型的绿色分离/富集技术，具有简单、省时、高效和绿色无污染等优点，已被应用于金属离子的定量分离萃取、生物活性物质的分离纯化以及天然产物的提取等领域。目前的双水相体系主要包括聚合物-聚合物双水相体系、聚合物-盐双水相体系、离子液体-盐双水相体系和小分子有机溶剂-盐双水相体系，但由于有机溶剂易挥发不稳定、离子液体成本较高和两种聚合物体系的粘度较大等问题，影响了这三种双水相体系在工业规模化生产中的应用。而聚合物-盐双水相体系用盐代替聚合物-聚合物双水相体系中的一种聚合物作为成相物质，在降低体系粘度和生产成本的同时，保留了聚合物生物相容性好的优势，被广泛应用于生物活性物质、天然产物及抗生素的分离纯化，具有较高的开发价值和广阔的应用前景。通过分析聚合物-盐双水相体系的理论及应用研究进展，希望对进一步的研究工作有所帮助和启发。
쌍수상췌취기술작위일충신형적록색분리/부집기술，구유간단、성시、고효화록색무오염등우점，이피응용우금속리자적정량분리췌취、생물활성물질적분리순화이급천연산물적제취등영역。목전적쌍수상체계주요포괄취합물-취합물쌍수상체계、취합물-염쌍수상체계、리자액체-염쌍수상체계화소분자유궤용제-염쌍수상체계，단유우유궤용제역휘발불은정、리자액체성본교고화량충취합물체계적점도교대등문제，영향료저삼충쌍수상체계재공업규모화생산중적응용。이취합물-염쌍수상체계용염대체취합물-취합물쌍수상체계중적일충취합물작위성상물질，재강저체계점도화생산성본적동시，보류료취합물생물상용성호적우세，피엄범응용우생물활성물질、천연산물급항생소적분리순화，구유교고적개발개치화엄활적응용전경。통과분석취합물-염쌍수상체계적이론급응용연구진전，희망대진일보적연구공작유소방조화계발。
Aqueous two phase extration is a new and green separation and enrichment technology,and it has some advantages,such as simple,timesaving,efficient,green and eco-friendly,and it has been applied to the quantitative separation and extraction of metal ions,separation and purification of bioactivator and extraction of natural product. The existent aqueous two-phase system included polymer-polymer aqueous two-phase system, polymer-salt aqueous two-phase system,ionic liquid-salt aqueous two-phase system and micromolecule organic solvent-salt aqueous two-phase system. Because organic solvent is volatile and instable,the price of ionic liquid is higher and the viscosity of system containing two polymer is larger,the application of these three types of aqueous two-phase systems in large-scale industrial production was affected. One polymer of polymer-polymer aqueous two-phase system was replaced by salt,and it is polymer-salt aqueous two-phase system. The cost and viscosity of polymer-salt aqueous two-phase system is cheaper,and it has the advantage of good biocompatibility. It is applied in the separation and enrichment of bioactivator,natural product and antibiotic,and has high-exploited value and broad prospects on its application. In this paper,the research progress on the polymer-salt aqueous two-phase system was given,and hoping that is will be of help fo further research.