医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2014年
3期
29-31
,共3页
林志凤%董桂凤%于美芹%陈增生
林誌鳳%董桂鳳%于美芹%陳增生
림지봉%동계봉%우미근%진증생
新生儿%重症监护室%病原菌%耐药性
新生兒%重癥鑑護室%病原菌%耐藥性
신생인%중증감호실%병원균%내약성
Newborn%Intensive Care Unit%Pathogens%Drug resistance
目的：了解青岛某妇女儿童医院新生儿重症监护病房血培养的细菌分布及耐药性特点。方法：对2013.1月-2013.12月青岛某妇女儿童医院新生儿重症监护病房（NICU）送检的血培养结果进行回顾性统计分析。结果：1年时间共收到新生儿重症监护病房血培养标本423例，培养阳性结果57例，占13.48%.其中革兰阳性菌31例，占54.39%，革兰阴性杆菌25例，占43.86%，真菌1例，占1.75%.各种革兰阳性菌均敏感的药物是万古霉素、利奈唑胺、呋喃妥因和替加环素，敏感性为100%；革兰阴性菌主要是大肠埃希菌和肺炎克雷伯菌。大肠埃希菌中产ESBLS株占37.5(3/8)，肺炎克雷伯菌种产ESBLS株为100%；这两种革兰阴性杆菌均敏感的药物是亚胺培南.、哌拉西林/他唑巴坦、厄他培南、阿米卡星和妥布霉素。结论：该院新生儿重症监护病房血培养病原菌中革兰阳性菌以凝固酶阴性菌为主，革兰阴性菌中主要是大肠埃希菌和肺炎克雷伯菌，各种细菌都在不同程度上表现为多重耐药性，应重视新生儿重症监护室血培养及药敏结果，根据药敏结果选用敏感性抗菌药物，以提高疗效，防止耐药菌的产生和传播。
目的：瞭解青島某婦女兒童醫院新生兒重癥鑑護病房血培養的細菌分佈及耐藥性特點。方法：對2013.1月-2013.12月青島某婦女兒童醫院新生兒重癥鑑護病房（NICU）送檢的血培養結果進行迴顧性統計分析。結果：1年時間共收到新生兒重癥鑑護病房血培養標本423例，培養暘性結果57例，佔13.48%.其中革蘭暘性菌31例，佔54.39%，革蘭陰性桿菌25例，佔43.86%，真菌1例，佔1.75%.各種革蘭暘性菌均敏感的藥物是萬古黴素、利奈唑胺、呋喃妥因和替加環素，敏感性為100%；革蘭陰性菌主要是大腸埃希菌和肺炎剋雷伯菌。大腸埃希菌中產ESBLS株佔37.5(3/8)，肺炎剋雷伯菌種產ESBLS株為100%；這兩種革蘭陰性桿菌均敏感的藥物是亞胺培南.、哌拉西林/他唑巴坦、阨他培南、阿米卡星和妥佈黴素。結論：該院新生兒重癥鑑護病房血培養病原菌中革蘭暘性菌以凝固酶陰性菌為主，革蘭陰性菌中主要是大腸埃希菌和肺炎剋雷伯菌，各種細菌都在不同程度上錶現為多重耐藥性，應重視新生兒重癥鑑護室血培養及藥敏結果，根據藥敏結果選用敏感性抗菌藥物，以提高療效，防止耐藥菌的產生和傳播。
목적：료해청도모부녀인동의원신생인중증감호병방혈배양적세균분포급내약성특점。방법：대2013.1월-2013.12월청도모부녀인동의원신생인중증감호병방（NICU）송검적혈배양결과진행회고성통계분석。결과：1년시간공수도신생인중증감호병방혈배양표본423례，배양양성결과57례，점13.48%.기중혁란양성균31례，점54.39%，혁란음성간균25례，점43.86%，진균1례，점1.75%.각충혁란양성균균민감적약물시만고매소、리내서알、부남타인화체가배소，민감성위100%；혁란음성균주요시대장애희균화폐염극뢰백균。대장애희균중산ESBLS주점37.5(3/8)，폐염극뢰백균충산ESBLS주위100%；저량충혁란음성간균균민감적약물시아알배남.、고랍서림/타서파탄、액타배남、아미잡성화타포매소。결론：해원신생인중증감호병방혈배양병원균중혁란양성균이응고매음성균위주，혁란음성균중주요시대장애희균화폐염극뢰백균，각충세균도재불동정도상표현위다중내약성，응중시신생인중증감호실혈배양급약민결과，근거약민결과선용민감성항균약물，이제고료효，방지내약균적산생화전파。
Objective: To investigate the characteristics of the distribution and drug resistance of bacteria in blood culture of neonatal intensive care unit of a Qingdao hospital for women and children.Methods:Blood culture results of the neonatal intensive care unit (NICU) from 2013.1 to 2013.12 in a Qingdao Hospital of Women and Children were analyzed retrospectively.Results:a annual 423 blood culture specimens were received, of which 57 cases were positive accounting for 13.48%. 31 cases of gram positive bacteria among positive cases accounted for 54.39%, 25 cases of gram negative bacilli accounted for 43.86% respectively, 1 fungi case accounted for 1.75% at last. The drugs which a variety of gram positive bacteria were on a 100% sensitivity to vancomycin, linezolid nitrofurantoin and tigecycline; Escherichia coli and Klebsiella pneumoniae of gram negative bacterias were also completely sensitive to these drugs. Of all Escherichia coli, ESBLS-producing-Escherichia coli accounted for 37.5%(3/8), Klebsiella pneumoniae were 100% ESBLS positive; both of the gram negative bacilli were sensitive to Imipenem, Piperacillin / tazobactam,Ertapenem, Amikacin and tobramycin.Conclusions:Most of the pathogen of gram positive bacteria in blood culture obtained from the NICU of the hospital were coagulase negative bacteria, meanwhile Escherichia coli and Klebsiella pneumoniae were the main member of gram negative ones. The blood culture results and bacteria sensitivity results of NICU should be pay attention to because of all kinds of bacteria were presenting resistant to multiple drugs. In order to improve the curative effect and prevent the occurrence and spread of resistant bacteria, antibacterials should be chosen effectively according to the results of drug sensitivity.
