医学检验与临床
醫學檢驗與臨床
의학검험여림상
MEDICAL LATORATORY SCIENCE AND CLINICES
2014年
3期
26-28,43
,共4页
ICU%病原菌分布%耐药性
ICU%病原菌分佈%耐藥性
ICU%병원균분포%내약성
Intensive care unit%The distribution of pathogens%Drug resistance
目的：调查重症监护病房(ICU)感染患者病原菌的分布及耐药情况，为临床合理选用抗菌药物提供依据。方法：采用VITEK-32全自动细菌鉴定系统及配套的GNI+、GNS-448和Etest、K-B纸片等方法对病原菌进行鉴定和药物敏感性试验。结果：526株病原菌分别来自呼吸道痰标本270株（51.5%）、血标本79株(15.0%)、尿标本61株(11.6%)、各种分泌物53株(10.1%)、脓液47株(8.9%)及16株其它标本(3.1%)；分离率前5位的细菌分别为铜绿假单胞菌、大肠埃希菌、肺炎克雷伯菌、鲍曼不动杆菌和金黄色葡萄球菌。革兰阴性杆菌对亚胺培南、哌拉西林/他唑巴坦、丁胺卡那霉素和左氧氟沙星耐药率较低（均<30.0%），革兰阳性球菌对万古霉素、利奈唑烷、替加环素及呋喃妥因等抗生素几乎完全敏感。结论：ICU感染患者病原菌种类较多，耐药率较高，临床医生应根据实验室药敏结果合理用药，减少耐药菌株的产生。
目的：調查重癥鑑護病房(ICU)感染患者病原菌的分佈及耐藥情況，為臨床閤理選用抗菌藥物提供依據。方法：採用VITEK-32全自動細菌鑒定繫統及配套的GNI+、GNS-448和Etest、K-B紙片等方法對病原菌進行鑒定和藥物敏感性試驗。結果：526株病原菌分彆來自呼吸道痰標本270株（51.5%）、血標本79株(15.0%)、尿標本61株(11.6%)、各種分泌物53株(10.1%)、膿液47株(8.9%)及16株其它標本(3.1%)；分離率前5位的細菌分彆為銅綠假單胞菌、大腸埃希菌、肺炎剋雷伯菌、鮑曼不動桿菌和金黃色葡萄毬菌。革蘭陰性桿菌對亞胺培南、哌拉西林/他唑巴坦、丁胺卡那黴素和左氧氟沙星耐藥率較低（均<30.0%），革蘭暘性毬菌對萬古黴素、利奈唑烷、替加環素及呋喃妥因等抗生素幾乎完全敏感。結論：ICU感染患者病原菌種類較多，耐藥率較高，臨床醫生應根據實驗室藥敏結果閤理用藥，減少耐藥菌株的產生。
목적：조사중증감호병방(ICU)감염환자병원균적분포급내약정황，위림상합리선용항균약물제공의거。방법：채용VITEK-32전자동세균감정계통급배투적GNI+、GNS-448화Etest、K-B지편등방법대병원균진행감정화약물민감성시험。결과：526주병원균분별래자호흡도담표본270주（51.5%）、혈표본79주(15.0%)、뇨표본61주(11.6%)、각충분비물53주(10.1%)、농액47주(8.9%)급16주기타표본(3.1%)；분리솔전5위적세균분별위동록가단포균、대장애희균、폐염극뢰백균、포만불동간균화금황색포도구균。혁란음성간균대아알배남、고랍서림/타서파탄、정알잡나매소화좌양불사성내약솔교저（균<30.0%），혁란양성구균대만고매소、리내서완、체가배소급부남타인등항생소궤호완전민감。결론：ICU감염환자병원균충류교다，내약솔교고，림상의생응근거실험실약민결과합리용약，감소내약균주적산생。
Objective: To study the distribution and drug-resistance of pathogenic bacteria of patients in intensive care unit (ICU), and instruct clinical application of antibiotics reasonably.Methods:All specimens isolated and cultured from patients in our hospital were identified and analyzed by using the automatic microorganism analyzer VITEK-32, Etest and K-B.Results:A total of 526 isolates were recovered from clinical specimens of patients in intensive care units ( ICUs) , from 270 respiratory specimens ( 51.5%) , 79 blood specimens ( 15.0%) , 61 urinary specimens ( 11.6%), 53 secretion specimens ( 10.1%) , 47 pus specimens ( 8.9%) ,and 16 the others(3.1%) . The top 5 most common organisms isolated were Pseudomonas aeruginosa, Escherichia coli , Klebsiella pneumoniae, Acitetobacter baumannii and Staphylococcus aureus. The gram-negagive.Conclusions:The kind of pathogens and rate of drug resistance in ICU are high, and the clinical should use antibiotics reasonably to reduce the rate of drug resistance.
