CAJ | 학술논문

目的微循环灌注的评价结果为早期发现脓毒症微循环改变提供了重要依据，基于血管分割得到的功能性毛细血管密度能够有效反映微血管灌注情况。方法首先，通过预处理操作改善图像的质量，增强血管与背景的对比度；其次利用自适应局部阈值法对图像进行初次分割，得到大致的血管区域；最后，通过后处理环节去除伪影并连接血管片段，根据最终血管分割结果计算功能性毛细血管密度。结果经过实际采集的舌下微循环血管数据的验证，上述方法与AVA软件测量结果的吻合率达到92%以上。结论上述方法可以快速准确地实现舌下微循环血流灌注的自动化评价，具有较强的临床应用价值。
목적미순배관주적평개결과위조기발현농독증미순배개변제공료중요의거，기우혈관분할득도적공능성모세혈관밀도능구유효반영미혈관관주정황。방법수선，통과예처리조작개선도상적질량，증강혈관여배경적대비도；기차이용자괄응국부역치법대도상진행초차분할，득도대치적혈관구역；최후，통과후처리배절거제위영병련접혈관편단，근거최종혈관분할결과계산공능성모세혈관밀도。결과경과실제채집적설하미순배혈관수거적험증，상술방법여AVA연건측량결과적문합솔체도92%이상。결론상술방법가이쾌속준학지실현설하미순배혈류관주적자동화평개，구유교강적림상응용개치。
Objective The assessment result of microcirculatory perfusion provides significant evidence for the detection of microcirculatory alterations in sepsis patients, and functional capilary density based on vessel segmentation can refl ect microcirculatory perfusion effectively.Methods First, preprocessing comprise operations to improve the quality of images in order to maximize the contrast between background and vessels. Secondly, adaptive local thresholding is used for initial segmentation to get the general vessel region. Finaly, post-processing technique reduces the image artifacts and links the vessel fragment, and then functional capilary density is calculated based on the segmentation results.Results Several sublingual microcirculatory data have been tested, and the agreement between the results by AVA and the proposed algorithm reached up to 92%.Conclusions The method can realize automated assessment of sublingual microcirculatory perfusion rapidly and accurately, and has strong clinical value.