国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
24期
1881-1884
,共4页
耐药%吸入抗生素%革兰阴性菌肺炎%机械通气%呼吸机相关性肺炎
耐藥%吸入抗生素%革蘭陰性菌肺炎%機械通氣%呼吸機相關性肺炎
내약%흡입항생소%혁란음성균폐염%궤계통기%호흡궤상관성폐염
Drug resistance%Aerosolized antibiotic%Gram-negative pneumonia%Mechanical ventilation%Ventilator-associated pneumonia
呼吸机相关性肺炎(ventilator-associated pneumonia,VAP)是机械通气患者常见的并发症,有着极高的病死率,全身静脉使用抗生素作为VAP的主要治疗措施,临床治愈率有限.从理论上讲,雾化吸入抗生素于局部达到较高的药物浓度,联合静脉使用抗生素,可取得更好的临床效果,特别是在VAP伴多重耐药菌感染及某些静脉抗生素效果不佳的治疗中.
呼吸機相關性肺炎(ventilator-associated pneumonia,VAP)是機械通氣患者常見的併髮癥,有著極高的病死率,全身靜脈使用抗生素作為VAP的主要治療措施,臨床治愈率有限.從理論上講,霧化吸入抗生素于跼部達到較高的藥物濃度,聯閤靜脈使用抗生素,可取得更好的臨床效果,特彆是在VAP伴多重耐藥菌感染及某些靜脈抗生素效果不佳的治療中.
호흡궤상관성폐염(ventilator-associated pneumonia,VAP)시궤계통기환자상견적병발증,유착겁고적병사솔,전신정맥사용항생소작위VAP적주요치료조시,림상치유솔유한.종이론상강,무화흡입항생소우국부체도교고적약물농도,연합정맥사용항생소,가취득경호적림상효과,특별시재VAP반다중내약균감염급모사정맥항생소효과불가적치료중.
Ventilator-associated pneumonia (VAP) is one of the most common complications with high morbidity rate in patients with mechanical ventilation all the time.As the main way of curing VAP,systemic venous use of antibiotics has the limitation of clinical cure rate.Theoretically,aerosolized antibiotics can achieve higher local drug concentration,combined with intravenous antibiotic therapy results in better response,especially in patients with multi-drug resistant organisms or nonresponding pneumonia.
