CAJ | 학술논문

目的：比较分析2012年和2013年儿科下呼吸道感染铜绿假单胞菌的耐药性，为临床合理应用抗菌药物提供科学依据。方法：对本院2012年和2013年儿科下呼吸道标本中分离的铜绿假单胞菌进行比较分析，用VITEK2微生物分析系统进行病原菌鉴定和药敏分析。结果：儿科下呼吸道标本共分离出82株铜绿假单胞菌，其中2012年分离出35株，多重耐药铜绿假单胞菌检出率为2．9％；2013年分离出47株，多重耐药铜绿假单胞菌检出率为4．3％。2013年儿科下呼吸道感染铜绿假单胞菌对环丙沙星、环丙沙星和氨曲南等8种抗菌药物的耐药率高于2012年，其耐药率均低于10％。结论：2013年儿科下呼吸道标本分离的铜绿假单胞菌对常用8种抗菌药物耐药率高于2012年，应用抗菌药物治疗儿科下呼吸道感染时，临床医师在经验用药后应根据致病菌的耐药特点和药敏结果，合理选用抗菌药物，从而有效控制和减缓细菌耐药性的发生。
목적：비교분석2012년화2013년인과하호흡도감염동록가단포균적내약성，위림상합리응용항균약물제공과학의거。방법：대본원2012년화2013년인과하호흡도표본중분리적동록가단포균진행비교분석，용VITEK2미생물분석계통진행병원균감정화약민분석。결과：인과하호흡도표본공분리출82주동록가단포균，기중2012년분리출35주，다중내약동록가단포균검출솔위2．9％；2013년분리출47주，다중내약동록가단포균검출솔위4．3％。2013년인과하호흡도감염동록가단포균대배병사성、배병사성화안곡남등8충항균약물적내약솔고우2012년，기내약솔균저우10％。결론：2013년인과하호흡도표본분리적동록가단포균대상용8충항균약물내약솔고우2012년，응용항균약물치료인과하호흡도감염시，림상의사재경험용약후응근거치병균적내약특점화약민결과，합리선용항균약물，종이유효공제화감완세균내약성적발생。
To compare drug resistance of Pseudomonas aeruginosa in lower respiratory tract infection in paediatric ward from 2012 to 2013 ,so as to provide scientific basis for clinical rational use of antibiotics .Methods:Compare drug resistance of Pseudomonas aeruginosa isolated from samples of lower respiratory tract infection in paediatric ward from 2012 to 2013 .using VITEK-2 microbiology a-nalysis system for the pathogen identification and drug sensitive .Results:A total of 82 strains of Pseudomonas aeruginosa were isolated ,a-mong which,35 strains were isolated in 2012.The detection rate of multi -resistant pseudomonas aeruginosa among all the isolated strains was 2.9%;47 strains were isolated in 2013 , The detection rate of multi -resistant pseudomonas aeruginosa among all the isolated strains was 4.3%.The resistance rate of Pseudomonas aeruginosa .The resistance rate of Pseudomonas aeruginosa to amikacin and ciprofloxacin and in 2013 were higher than that in 2012 .;and the resistance rates were all lower than 10%.Conclusion:The drug resistance rate of Pseudomonas aeruginosa in 2013 to 8 familiar kinds of antibacterial drugs was higher than that in 2012 in lower respiratory tract infection in paediatric ward .For application of antibacterial drugs in the treatment of such bacterial infection , more attention should be paid to strengthening the monitoring of susceptibility changes in clinical infectious bacteria ,targeted selection of antibacterial drugs with high sen-sitivity,in order to effective control and reduce the incidence of bacterial drug resistance .