临床和实验医学杂志
臨床和實驗醫學雜誌
림상화실험의학잡지
JOURNAL OF CLINICAL AND EXPERIMENTAL MEDICINE
2014年
16期
1379-1381,1382
,共4页
田瑛%任东伟%张娟%王红
田瑛%任東偉%張娟%王紅
전영%임동위%장연%왕홍
病毒感染%细胞免疫%淋巴细胞亚群
病毒感染%細胞免疫%淋巴細胞亞群
병독감염%세포면역%림파세포아군
Epstein-Barr Virus%Cytomegalovirus%Lymphocyte subsets
目的通过检测不同病毒感染急性期患者外周血淋巴细胞亚群,比较其差异,了解不同病毒感染对宿主细胞免疫功能的影响并分析其临床意义。方法收集2010~2013年感染科门诊及住院收治的51例病毒感染急性期患者及20例正常对照,检测其外周血淋巴细胞亚群,比较其差异并分析临床意义。结果与正常对照相比,病毒感染患者外周血NK细胞、B细胞比率减少,T细胞比率升高;T细胞亚群中CD4﹢CD28﹢T细胞和CD8﹢CD28﹢T细胞比率降低, ;CD8﹢T细胞以及CD8﹢CD38﹢T细胞比率升高。EB病毒感染后T细胞、CD8﹢T细胞、CD8﹢CD38﹢T细胞比率升高较其他病毒感染更为显著。结论病毒感染患者存在免疫功能紊乱,天然免疫、体液免疫及细胞免疫功能下降同时伴有细胞免疫异常激活,EB病毒感染较其他病毒免疫激活更为明显。
目的通過檢測不同病毒感染急性期患者外週血淋巴細胞亞群,比較其差異,瞭解不同病毒感染對宿主細胞免疫功能的影響併分析其臨床意義。方法收集2010~2013年感染科門診及住院收治的51例病毒感染急性期患者及20例正常對照,檢測其外週血淋巴細胞亞群,比較其差異併分析臨床意義。結果與正常對照相比,病毒感染患者外週血NK細胞、B細胞比率減少,T細胞比率升高;T細胞亞群中CD4﹢CD28﹢T細胞和CD8﹢CD28﹢T細胞比率降低, ;CD8﹢T細胞以及CD8﹢CD38﹢T細胞比率升高。EB病毒感染後T細胞、CD8﹢T細胞、CD8﹢CD38﹢T細胞比率升高較其他病毒感染更為顯著。結論病毒感染患者存在免疫功能紊亂,天然免疫、體液免疫及細胞免疫功能下降同時伴有細胞免疫異常激活,EB病毒感染較其他病毒免疫激活更為明顯。
목적통과검측불동병독감염급성기환자외주혈림파세포아군,비교기차이,료해불동병독감염대숙주세포면역공능적영향병분석기림상의의。방법수집2010~2013년감염과문진급주원수치적51례병독감염급성기환자급20례정상대조,검측기외주혈림파세포아군,비교기차이병분석림상의의。결과여정상대조상비,병독감염환자외주혈NK세포、B세포비솔감소,T세포비솔승고;T세포아군중CD4﹢CD28﹢T세포화CD8﹢CD28﹢T세포비솔강저, ;CD8﹢T세포이급CD8﹢CD38﹢T세포비솔승고。EB병독감염후T세포、CD8﹢T세포、CD8﹢CD38﹢T세포비솔승고교기타병독감염경위현저。결론병독감염환자존재면역공능문란,천연면역、체액면역급세포면역공능하강동시반유세포면역이상격활,EB병독감염교기타병독면역격활경위명현。
Objective To investigate the different changes of host's cellular immunity in patients with different virus infection by comparing peripheral blood lymphocyte subsets. Methods Flow cytometry was used to detect the peripheral blood lymphocyte subsets among 51 patients infected with Epstein - Barr virus,cytomegalovirus or other virus. Results In contrast to the normal controls,percentage of T cells increased, and percentage of B/ NK cells decreased among the patients with acute virus infection. Meanwhile,within T cell subsets,percentage of CD8 ﹢ T cells and CD8 ﹢ CD38 ﹢ T cells increased;and percentage of CD4 ﹢ CD28 ﹢ T cells and CD8 ﹢ CD28 ﹢ T cells decreased. And percentage of T cells, CD8 ﹢ T cells and CD8 ﹢ CD38 ﹢ T cells was higher among the patients infected with Epstein - Barr virus than that among the patients infected with cytomegalovirus or other virus. Conclusion There was immune turbulence among patients with virus infection. Natural immunity,humoral immunity and cellular immunity all decreased while cellular immunity activated abnormally. The immune activation of the patients infected with Epstein - Barr virus was more obvious than that of patients infected with other virus.