CAJ | 학술논문

目的探讨老年2型糖尿病患者轻度认知功能障碍（ MCI）与胰岛素抵抗的关系。方法选择老年2型糖尿病患者合并MCI患者86例为研究组，匹配无MCI的2型糖尿病患者86例为对照组，检测比较空腹血糖（ FPG）、总胆固醇（ TC）、低密度脂蛋白胆固醇（ LDL-C）、糖化血红蛋白（ HbA1c）、空腹胰岛素（ FINS）等指标，评估胰岛素抵抗指数（ HOMA-IR），并分为胰岛素抵抗（ IR）组和非IR组，分析影响患者MCI发生的因素。结果研究组FPG、LDL-C、FINS、HbA1c 、HOMA-IR显著高于对照组。IR组MMSE评分、CMS评分显著低于非IR组，CMS评分中的各项目也显著低于非IR组。结论 HOMA-IR、FINS、FPG、LDL-C是老年2型糖尿病患者MCI发生的重要独立影响因素。IR是老年2型糖尿病患者MCI发生的重要影响因素，应采取治疗措施，降低其认知功能障碍的发生率。
목적탐토노년2형당뇨병환자경도인지공능장애（ MCI）여이도소저항적관계。방법선택노년2형당뇨병환자합병MCI환자86례위연구조，필배무MCI적2형당뇨병환자86례위대조조，검측비교공복혈당（ FPG）、총담고순（ TC）、저밀도지단백담고순（ LDL-C）、당화혈홍단백（ HbA1c）、공복이도소（ FINS）등지표，평고이도소저항지수（ HOMA-IR），병분위이도소저항（ IR）조화비IR조，분석영향환자MCI발생적인소。결과연구조FPG、LDL-C、FINS、HbA1c 、HOMA-IR현저고우대조조。IR조MMSE평분、CMS평분현저저우비IR조，CMS평분중적각항목야현저저우비IR조。결론 HOMA-IR、FINS、FPG、LDL-C시노년2형당뇨병환자MCI발생적중요독립영향인소。IR시노년2형당뇨병환자MCI발생적중요영향인소，응채취치료조시，강저기인지공능장애적발생솔。
Objective To explore the relationship between mild cognitive impairment( MCI)and insulin resistance in elderly patients with type 2 diabetes. Methods A total of 86 elderly patients with type 2 diabetes and MCI were allocated in study group,and 86 patients with type 2 diabetes without MCI were enrolled in control group. The levels of fasting glucose(FPG),total cholesterol(TC),low - density lipoprotein cholesterol(LDL - C),glycosylated hemoglobin(HbA1c),fasting insulin(FINS)and other indicators were detected. In accordance with the assessment of insulin resistance index(HOMA - IR),they were divided into IR group and non - IR group. The factors affecting the occurrence of MCI had been analyzed. Results Levels of FPG,LDL - C,FINS,HbA1c and HOMA - IR were significantly higher in study group. MMSE scores and CMS scores in patients of IR group were significantly lower than those of patients in non - IR group,and CMS scores in patients of IR group were also significantly lower than those of patients in non - IR group. Levels of HOMA - IR,FINS,FPG and LDL - C were important independent risk factors for MCI in elderly patients with type 2 diabetes. Conclusion Insulin resistance is an important factor in elderly patients with type 2 diabetes associated with MCI. Measures for treatment of ths condition should be taken in order to reduce the incidence of cognitive dysfunction in patients with type 2 diabetes.