CAJ | 학술논문

目的评价血清生殖激素测定在男性不育症病因学诊断及判定睾丸受损部位及治疗选择中的临床价值。方法用化学发光免疫分析法对96例男性不育症患者和25例正常生育男性进行了血清生殖激素[促卵泡生成素（ FSH）、促黄体生成素（LH）、睾酮（T）、泌乳素（PR）和雌二醇（E2）]检测，并结合睾丸容积测定等进行分析。结果不育症患者FSH、LH水平显著高于对照组（ P ﹤0.05），T显著低于对照组（ P ﹤0.05）。96例不育症中生殖激素水平异常55例，异常发生率为57.3%，高泌乳素血症、睾丸功能障碍、特发性少精症发生分别占前3位。无精子症中睾丸发育不良组的FSH、LH和PRL均高于睾丸发育正常组，T和E2均低于睾丸发育正常组，均具有统计学差异（ P ﹤0.01，P ﹤0.05）。结论男性生殖激素水平异常与少弱精子症、死精子症、无精子症的发生密切相关，血清中FSH、LH、PRL、T和E2水平可预测睾丸受损部位，对判断导致精子生成减少、活动减弱的内分泌学病因，选择治疗及预后判断具有重要的临床价值。
목적평개혈청생식격소측정재남성불육증병인학진단급판정고환수손부위급치료선택중적림상개치。방법용화학발광면역분석법대96례남성불육증환자화25례정상생육남성진행료혈청생식격소[촉란포생성소（ FSH）、촉황체생성소（LH）、고동（T）、비유소（PR）화자이순（E2）]검측，병결합고환용적측정등진행분석。결과불육증환자FSH、LH수평현저고우대조조（ P ﹤0.05），T현저저우대조조（ P ﹤0.05）。96례불육증중생식격소수평이상55례，이상발생솔위57.3%，고비유소혈증、고환공능장애、특발성소정증발생분별점전3위。무정자증중고환발육불량조적FSH、LH화PRL균고우고환발육정상조，T화E2균저우고환발육정상조，균구유통계학차이（ P ﹤0.01，P ﹤0.05）。결론남성생식격소수평이상여소약정자증、사정자증、무정자증적발생밀절상관，혈청중FSH、LH、PRL、T화E2수평가예측고환수손부위，대판단도치정자생성감소、활동감약적내분비학병인，선택치료급예후판단구유중요적림상개치。
Objective To investigate the relationship between testicular damage and endocrinology diagnosis with the reproduction hormone level detecting in patients with male Infertile,and provide the reference for clinical diagnosis and treatment. Methods Serum sex hormone including FSH,LH,T,PRL and E2 was detected by chemiluminescent immunoassay in the 96 patients with male infertile and volume of the testes was analysised by synthesis. Results FSH and LH level in serum of male infertile group were significantly higher than in control group( P ﹤ 0. 05),T level in serum were significantly lower than in control group( P ﹤0. 05). The rate of abnormal hormone level was 57. 3% in the 96 patients with male infertile. Hyperprolactinemia,testicular dysfunction and idiopathic oligospermia were the head of three in abnormal hormone level group. In testicular volume ﹤8 ml with azoospermatism group,FSH,LH and PRL level in serum were significantly higher than in ≥8 ml group, T and E2 level in serum were significantly lower than in ≥8 ml group( P ﹤0. 01,P ﹤0. 05). Conclusion The abnormal reproduction hormone level is closely related to oligospermia,asthenospermia and azoospermia. FSH,LH,T,PRL and E2 level in serum may predict not only testicular damage parts but also endocrinology diagnosis,treatment and prognosis in patients with the male infertile.