CAJ | 학술논문

目的了解淋巴结微转移与患者术后生存时间的关系。方法利用免疫组化法检测临床分期为Ⅰ期的、常规病理检查阴性的肺鳞癌（ SCC）患者淋巴结中细胞角蛋白表达水平判定淋巴结微转移，分析淋巴结微转移与预后之间的关系。结果淋巴结有微转移患者的生存率明显低于无微转移患者，差异有统计学意义（χ2＝2.02，P ＝0.0000）。结论肺鳞癌有淋巴结微转移患者较无微转移患者生存率低。
목적료해림파결미전이여환자술후생존시간적관계。방법이용면역조화법검측림상분기위Ⅰ기적、상규병리검사음성적폐린암（ SCC）환자림파결중세포각단백표체수평판정림파결미전이，분석림파결미전이여예후지간적관계。결과림파결유미전이환자적생존솔명현저우무미전이환자，차이유통계학의의（χ2＝2.02，P ＝0.0000）。결론폐린암유림파결미전이환자교무미전이환자생존솔저。
Objective To study the significance of expression of CK in patients with micrometastasis in lymph nodes as well as to explore the relationship between the survival time of patients with phase ⅠSCC and micrometastasis in lymph nodes,in order to provide a theoretical basis for treatment and evaluation of the prognosis of patients with phase Ⅰ SCC. Methods By using immunohistochemical SP method for detection of expression of CK protein in NSCLC patients with negative routine pathological examination for the presence of micrometastasis in hilar and mediastinal lymph nodes,and the evaluation of significance of CK expression in lymph nodes with micrometastasis was carried out in order to analyze the relationship between level of CK and the prognosis of these patients. Results The survival rate of patients with micrometastasis in lymph nodes was significantly lower than that of patients without micrometastasis,and their difference was statistically significan(t χ 2 =2. 02,P =0. 0000). Conclusion CK protein as a molecular marker for detection of micrometastasis in lymph nodes of patients with lung cancer is highly sensitive,and it is helpful in identification of micrometastasis in lymph nodes,and these patients have lower survival rate than those without micrometastasis.