中医临床研究
中醫臨床研究
중의림상연구
CLINICAL JOURNAL OF CHINESE MEDICINE
2014年
19期
57-58
,共2页
溃疡性结肠炎%甘草泻心汤%TNF-α%IL-6
潰瘍性結腸炎%甘草瀉心湯%TNF-α%IL-6
궤양성결장염%감초사심탕%TNF-α%IL-6
Ulcerative colitis%Gancao Xiexin decoction%TNF-α%IL-6
目的：观察甘草泻心汤加味方治疗溃疡性结肠炎的临床疗效及对相关炎性因子的影响。方法：62例溃疡性结肠炎患者随机分成两组，治疗组（34例）口服甘草泻心汤加味方进行治疗，对照组（28例）口服柳氮磺胺吡啶肠溶片治疗，疗程8周。观察两组的临床疗效以及治疗前后肿瘤坏死因子α（TNF-α）、白介素6（IL-6）水平的变化。结果：治疗组总有效率91.18%，对照组总有效率71.43%，疗效有显著性差异（P<0.05）。两组治疗后血 TNF-α、IL-6水平均较治疗前有降低，治疗组更为明显。结论：甘草泻心汤加味方治疗溃疡性结肠炎疗效显著，并对相关的TNF-α、IL-6水平有调节作用。
目的：觀察甘草瀉心湯加味方治療潰瘍性結腸炎的臨床療效及對相關炎性因子的影響。方法：62例潰瘍性結腸炎患者隨機分成兩組，治療組（34例）口服甘草瀉心湯加味方進行治療，對照組（28例）口服柳氮磺胺吡啶腸溶片治療，療程8週。觀察兩組的臨床療效以及治療前後腫瘤壞死因子α（TNF-α）、白介素6（IL-6）水平的變化。結果：治療組總有效率91.18%，對照組總有效率71.43%，療效有顯著性差異（P<0.05）。兩組治療後血 TNF-α、IL-6水平均較治療前有降低，治療組更為明顯。結論：甘草瀉心湯加味方治療潰瘍性結腸炎療效顯著，併對相關的TNF-α、IL-6水平有調節作用。
목적：관찰감초사심탕가미방치료궤양성결장염적림상료효급대상관염성인자적영향。방법：62례궤양성결장염환자수궤분성량조，치료조（34례）구복감초사심탕가미방진행치료，대조조（28례）구복류담광알필정장용편치료，료정8주。관찰량조적림상료효이급치료전후종류배사인자α（TNF-α）、백개소6（IL-6）수평적변화。결과：치료조총유효솔91.18%，대조조총유효솔71.43%，료효유현저성차이（P<0.05）。량조치료후혈 TNF-α、IL-6수평균교치료전유강저，치료조경위명현。결론：감초사심탕가미방치료궤양성결장염료효현저，병대상관적TNF-α、IL-6수평유조절작용。
To observe clinical efficacy of the Gancao Xiexin decoction on ulcerative colitis and intervention on related inflammatory cytokines. Methods:62 patients were randomly divided into two groups, the treatment group was given the Gancao Xiexin decoction, the control was given Sulfasalazine enteric-coated tablets. In 8 weeks, clinical efficacy and levels of TNF-αand IL-6 before and after treatment were recorded in both. Results:The total efficacy in the treatment was 91.18%and 71.43%in the control, the difference was statistically significant(P<0.05);TNF-αand IL-6 decreased in both, it was more obvious in the treatment. Conclusion:The Gancao Xiexin decoction was effective on ulcerative colitis, and could regulate levels of TNF-αand IL-6.
