CAJ | 학술논문

目的探讨单一病灶皮层下脑梗死患者在发病后不同时间点分别从事特征工作记忆和整合工作记忆时的认知行为特点.方法 28例单一病灶皮层下脑梗死患者,25名年龄、性别及文化程度相匹配的健康志愿者为对照在实验期间进行一次相同任务测试.在发病基线(W1)、发病3个月(M3)以及发病6个月(M6)分别从事颜色、空间和颜色-空间整合3种工作记忆延迟匹配样本任务,计算机记录其行为反应时间和正确率,并统计学分析.结果 W1与M3比较,3种记忆任务的正确率[(61.06±7.78)％,(64.92±5.47)％；(90.59±2.95)％,(92.88±2.98)％；(77.06±5.58)％,(82.35±7.44)％]均有提高,其反应时间[(914.02±110.53) ms,(868.31±118.91) ms；(859.89±139.94)ms,(833.37±120.99)ms；(1150.17 ±92.02) ms,(918.72±101.28)ms]缩短,差异有统计学意义(P＜0.05)；M6与M3比较,空间任务的正确率[(93.91±2.86)％；(92.88±2.98)％]进一步提高,反应时间[(813.24±119.54)ms；(833.37±120.99) ms]缩短,而颜色任务的正确率[(64.50±4.49)％；(64.92±5.47)％]和反应时间[(866.47±123.87)ms; (868.31±118.91)ms]差异无统计学意义(P＞0.05),整合任务的正确率[(78.49±7.85)％；(82.35±7.44)％]却有显著性下降(P＜0.05),几乎降至发病基线水平[(77.06±5.58)％]；与对照组相比,除M6时空间记忆指标[(93.91±2.86)％；(813.24±119.54)ms]差异无统计学意义(P＞0.05),其余均差异有统计学意义.结论单一病灶皮层下脑梗死患者在发病后特征及整合记忆均有不同程度损害,半年时空间记忆基本恢复至正常,但整合记忆存在继发性损害,这可能与脑梗死后神经纤维继发性损害有关.
목적 탐토단일병조피층하뇌경사환자재발병후불동시간점분별종사특정공작기억화정합공작기억시적인지행위특점.방법 28례단일병조피층하뇌경사환자,25명년령、성별급문화정도상필배적건강지원자위대조재실험기간진행일차상동임무측시.재발병기선(W1)、발병3개월(M3)이급발병6개월(M6)분별종사안색、공간화안색-공간정합3충공작기억연지필배양본임무,계산궤기록기행위반응시간화정학솔,병통계학분석.결과 W1여M3비교,3충기억임무적정학솔[(61.06±7.78)％,(64.92±5.47)％；(90.59±2.95)％,(92.88±2.98)％；(77.06±5.58)％,(82.35±7.44)％]균유제고,기반응시간[(914.02±110.53) ms,(868.31±118.91) ms；(859.89±139.94)ms,(833.37±120.99)ms；(1150.17 ±92.02) ms,(918.72±101.28)ms]축단,차이유통계학의의(P＜0.05)；M6여M3비교,공간임무적정학솔[(93.91±2.86)％；(92.88±2.98)％]진일보제고,반응시간[(813.24±119.54)ms；(833.37±120.99) ms]축단,이안색임무적정학솔[(64.50±4.49)％；(64.92±5.47)％]화반응시간[(866.47±123.87)ms; (868.31±118.91)ms]차이무통계학의의(P＞0.05),정합임무적정학솔[(78.49±7.85)％；(82.35±7.44)％]각유현저성하강(P＜0.05),궤호강지발병기선수평[(77.06±5.58)％]；여대조조상비,제M6시공간기억지표[(93.91±2.86)％；(813.24±119.54)ms]차이무통계학의의(P＞0.05),기여균차이유통계학의의.결론 단일병조피층하뇌경사환자재발병후특정급정합기억균유불동정도손해,반년시공간기억기본회복지정상,단정합기억존재계발성손해,저가능여뇌경사후신경섬유계발성손해유관.
Objective To investigate the cognitive behavioral characteristic longitudinally of the patients after subcortical infarction engaged in feature and binding working memory tasks.Methods The behavioral performances were recorded from 28 patients after subcortical infarction at the 1 st week (W1),3 rd moth (M3) and 6th month (M6) while performing color,location,and color-location binding delayed match-to-sample working memory task.25 healthy volunteers(controls) were investigated once using the same task protocol during the study period.Computer recorded the behavior reaction time and accuracy.Single factor variant analysis of repeated measurement was adopted.Results The accuracy of three memory tasks of M3 ((64.92 ± 5.47) ％ ; (92.88 ± 2.98) ％ ;(82.35 ±7.44)％) was improved than that of W1 ((61.06 ±7.78)％; (90.59 ±2.95)％; (77.06 ±5.58) ％) and the difference had statistically significant (P ＜ 0.05).But the reaction time of M3 ((868.31 ±118.91)ms; (833.37 ± 120.99) ms; (918.72 ± 101.28) ms) was shortened than that of W1 ((914.02 ±110.53) ms; (859.89 ± 139.94) ms; (1150.17 ± 92.02) ms) and the difference also had statistically significant (P ＜ 0.05).In the location-memory task,the correct rate of M6 ((93.91 ± 2.86) ％) was improved than that of M3 ((92.88 ± 2.98) ％) and the reaction time of M6 ((813.24 ± 119.54) ms) was shortened than M3 ((833.37 ±120.99) ms).M6 and M3 to be compared in the color memory task,the correct rate ((64.50 ± 4.49) ％ ; (64.92 ± 5.47) ％) and the reaction time ((866.47 ± 123.87) ms; (868.31 ± 118.91) ms) had no significant difference (P ＜ 0.05).But in the color-location binding task,the correct rate of M6 ((78.49 ± 7.85) ％) and M3 ((82.35 ± 7.44)％) to be compared had significant decreased nearly the level ((77.06 ± 5.58)％) of the stroke beginning.All behavioral performances of patients were worse than that of control subjects except the compare result of location-memory task in M6((93.91 ± 2.86) ％ ; (813.24 ± 119.54) ms).Conclusion Feature memory and binding memory had been damaged in different degrees in the patient after subcortical infarction.The binding memory had the secondary damage what might be related to the secondary nerve fiber degeneration after infarction.