中国实用医药
中國實用醫藥
중국실용의약
CHINA PRACTICAL MEDICAL
2014年
19期
4-5
,共2页
谭娅琴%杨香菊%廖庆辉%万新红%陈玉华
譚婭琴%楊香菊%廖慶輝%萬新紅%陳玉華
담아금%양향국%료경휘%만신홍%진옥화
糖尿病周围神经病变%α-硫辛酸%氧化应激
糖尿病週圍神經病變%α-硫辛痠%氧化應激
당뇨병주위신경병변%α-류신산%양화응격
Diabetic peripheral neuropathy%Alpha lipoic acid%Oxidative stress
目的:探讨α-硫辛酸在二甲双胍治疗糖尿病周围神经病变中对患者氧化应激的改善作用。方法50例糖尿病周围神经病变患者随机分为治疗组和对照组各25例,治疗组给予二甲双胍联合α-硫辛酸治疗;对照组给予二甲双胍治疗。比较两组治疗前后感觉神经传导速度(SCV)的变化。结果两组治疗后正中神经和腓神经的SCV均高于治疗前,且治疗组高于对照组,差异有统计学意义(P<0.05)。α-硫辛酸能降低血清中丙二醛(MDA)水平并提高超氧化物歧化酶(SOD)水平。结论α-硫辛酸能改善糖尿病周围神经病变,这可能是通过改善氧化应激来实现的。
目的:探討α-硫辛痠在二甲雙胍治療糖尿病週圍神經病變中對患者氧化應激的改善作用。方法50例糖尿病週圍神經病變患者隨機分為治療組和對照組各25例,治療組給予二甲雙胍聯閤α-硫辛痠治療;對照組給予二甲雙胍治療。比較兩組治療前後感覺神經傳導速度(SCV)的變化。結果兩組治療後正中神經和腓神經的SCV均高于治療前,且治療組高于對照組,差異有統計學意義(P<0.05)。α-硫辛痠能降低血清中丙二醛(MDA)水平併提高超氧化物歧化酶(SOD)水平。結論α-硫辛痠能改善糖尿病週圍神經病變,這可能是通過改善氧化應激來實現的。
목적:탐토α-류신산재이갑쌍고치료당뇨병주위신경병변중대환자양화응격적개선작용。방법50례당뇨병주위신경병변환자수궤분위치료조화대조조각25례,치료조급여이갑쌍고연합α-류신산치료;대조조급여이갑쌍고치료。비교량조치료전후감각신경전도속도(SCV)적변화。결과량조치료후정중신경화비신경적SCV균고우치료전,차치료조고우대조조,차이유통계학의의(P<0.05)。α-류신산능강저혈청중병이철(MDA)수평병제고초양화물기화매(SOD)수평。결론α-류신산능개선당뇨병주위신경병변,저가능시통과개선양화응격래실현적。
Objective To explore improving effect of alpha-lipoic acid in relieving oxidative stress for diabetic peripheral neuropathy patients with metformin treatment.MethodsSelected 50 patients with DPN in our hospital and randomly divided them into observation group and control group, 25 cases in each group, both groups receiving metformin for 30 days, observation group was given intravenously ALA. The nerve conduction velocity, serum level of malonaldehyde(MDA) and superoxide dismutase(SOD) were compared before and after treatment in both groups.ResultsCompared with control group, the MDA was significantly decreased (P<0.01), SOD was significantly increased (P<0.01), the nerve conduction velocity increased significantly in observation group after treatment(P<0.01).ConclusionALA can effectively improve the clinical symptoms, increase nerve conduction velocity by lightening the oxidative stress of the DPN patients.