医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
21期
651-652
,共2页
张云芳(综述)%王玉明%段勇(审校)
張雲芳(綜述)%王玉明%段勇(審校)
장운방(종술)%왕옥명%단용(심교)
Runx2%锁骨颅骨发育不良综合征%骨质疏松症%骨肉瘤%脊柱后纵韧带骨化
Runx2%鎖骨顱骨髮育不良綜閤徵%骨質疏鬆癥%骨肉瘤%脊柱後縱韌帶骨化
Runx2%쇄골로골발육불량종합정%골질소송증%골육류%척주후종인대골화
Runx2%Cleidocranialdysostosis%Osteoporosis%Osteosarcoma%Ossification of the posterior longitudinal ligament
Runx2是骨发育过程中调节骨髓间充质干细胞向成骨细胞分化和成熟最关键的转录因子,它通过多条途径参与骨代谢的调控,可影响成骨细胞及破骨细胞活动从而控制骨形成与骨吸收,并与很多骨相关疾病的形成有很大关系,Runx2基因多态性的研究为疾病的早发现及治疗提供新的思路及治疗靶点。
Runx2是骨髮育過程中調節骨髓間充質榦細胞嚮成骨細胞分化和成熟最關鍵的轉錄因子,它通過多條途徑參與骨代謝的調控,可影響成骨細胞及破骨細胞活動從而控製骨形成與骨吸收,併與很多骨相關疾病的形成有很大關繫,Runx2基因多態性的研究為疾病的早髮現及治療提供新的思路及治療靶點。
Runx2시골발육과정중조절골수간충질간세포향성골세포분화화성숙최관건적전록인자,타통과다조도경삼여골대사적조공,가영향성골세포급파골세포활동종이공제골형성여골흡수,병여흔다골상관질병적형성유흔대관계,Runx2기인다태성적연구위질병적조발현급치료제공신적사로급치료파점。
Runx2 is the key transcription factor of regulating the bone marrow mesenchymal stem cells into osteoblasts dif erentiation and maturation during bone development. Through many pathways involved in the regulation of bone metabolism, Runx2 Can af ect osteoblasts, osteoclast activity and control bone resorption and formation, and have a great relationship with the formation of many bone-related diseases, Thus providing new ideas and therapeutic targets for the early detection and treatment of these diseases.