CAJ | 학술논문

目的：观察脱氢表雄酮治疗卵巢储备功能下降患者的临床疗效。方法：选取本院收治的80例卵巢储备功能下降患者为研究对象，随机分为观察组和对照组各40例。其中观察组口服脱氢表雄酮（25mg）bid，连续治疗3个月；对照组采用补佳乐+达芙通治疗3个月。治疗结束后观察窦状卵泡数（AFC），卵巢最大平面直径、及性激素（FSH、LH、FSH/H、E2、T）水平和抗苗勒氏管激素（AMH）的变化情况。结果：观察组治疗后月经第3天血清 FSH水平较治疗前降低(P＜0.05)，AMH水平较治疗前升高（P＜0.05），AFC增加（P＜0.05）。与对照组相比，血清FSH、LH、FSH /LH、E2、AMH水平差异无统计学意义。结论：脱氢表雄酮可降低血清 FSH，升高AMH，增加窦状卵泡数，可改善卵巢储备功能。
목적：관찰탈경표웅동치료란소저비공능하강환자적림상료효。방법：선취본원수치적80례란소저비공능하강환자위연구대상，수궤분위관찰조화대조조각40례。기중관찰조구복탈경표웅동（25mg）bid，련속치료3개월；대조조채용보가악+체부통치료3개월。치료결속후관찰두상란포수（AFC），란소최대평면직경、급성격소（FSH、LH、FSH/H、E2、T）수평화항묘륵씨관격소（AMH）적변화정황。결과：관찰조치료후월경제3천혈청 FSH수평교치료전강저(P＜0.05)，AMH수평교치료전승고（P＜0.05），AFC증가（P＜0.05）。여대조조상비，혈청FSH、LH、FSH /LH、E2、AMH수평차이무통계학의의。결론：탈경표웅동가강저혈청 FSH，승고AMH，증가두상란포수，가개선란소저비공능。
To observe dhea therapy in patients with ovarian reserve function by clinical curative effect. Selection methods in our hospital treated 80 cases of ovarian reserve function decline in patients as the research object, were randomly divided into observation group and control group (n = 40). The observation group oral dhea (25 mg) bid, continuous treatment for 3 months; Control group replacement jiale + duff treatment for 3 months. Observation after treatment sinus follicle number (AFC), ovarian biggest plane diameter, and sex hormone (FSH, LH, FSH, E2, T/H) level and the resistance of seedlings le's changes of the tube hormone (AMH). Results observation group 3 days after treatment serum FSH level was lower (P<0.05), the AMH level higher than before treatment (P<0.05), an AFC increased (P<0.05). Compared with the control group, serum FSH, LH, FSH/LH, E2, there was no statistically significant difference AMH level. Conclusion dehydroepiandrosterone (dhea) can decrease the serum FSH, higher AMH, increase sinus follicle number, can improve the ovarian reserve function.