医学信息
醫學信息
의학신식
MEDICAL INFORMATION
2014年
21期
49-50
,共2页
孙晓佳%郝彩玲%丁楠%赵琦
孫曉佳%郝綵玲%丁楠%趙琦
손효가%학채령%정남%조기
血管内皮生长因子%血管内皮生长因子受体2%Dl 4%Notch1%肿瘤,基底细胞%鲍温病%血管生成
血管內皮生長因子%血管內皮生長因子受體2%Dl 4%Notch1%腫瘤,基底細胞%鮑溫病%血管生成
혈관내피생장인자%혈관내피생장인자수체2%Dl 4%Notch1%종류,기저세포%포온병%혈관생성
Vascular endothelial growth factor%Vascular endothelial growth factor receptor 2%Dl 4%Notch1%Tumor,Basal cel%Bowen's disease%Angiogenesis
目的：比较VEGF-VEGFR2,Dl 4-Notch1信号通路在不同类型上皮源性肿瘤中的表达及关系。方法采用免疫组化方法,对60例基底细胞癌和26例鲍温病的石蜡包埋标本进行VEGF、VEGFR2、Dl 4、Notch1蛋白水平的检测,并进行相关性分析。结果 VEGF、VEGFR2、在基底细胞癌中的表达高于鲍温病及正常皮肤组织,差异具有统计学意义(P<0.05)。而Dl 4、Notch1在基底细胞癌中的表达低于鲍温病及正常皮肤组织,差异具有统计学意义(P<0.05)。结论 VEGF、VEGFR2、Dl 4、Notch1与不同种类上皮源性皮肤肿瘤的发展和预后有关。
目的：比較VEGF-VEGFR2,Dl 4-Notch1信號通路在不同類型上皮源性腫瘤中的錶達及關繫。方法採用免疫組化方法,對60例基底細胞癌和26例鮑溫病的石蠟包埋標本進行VEGF、VEGFR2、Dl 4、Notch1蛋白水平的檢測,併進行相關性分析。結果 VEGF、VEGFR2、在基底細胞癌中的錶達高于鮑溫病及正常皮膚組織,差異具有統計學意義(P<0.05)。而Dl 4、Notch1在基底細胞癌中的錶達低于鮑溫病及正常皮膚組織,差異具有統計學意義(P<0.05)。結論 VEGF、VEGFR2、Dl 4、Notch1與不同種類上皮源性皮膚腫瘤的髮展和預後有關。
목적：비교VEGF-VEGFR2,Dl 4-Notch1신호통로재불동류형상피원성종류중적표체급관계。방법채용면역조화방법,대60례기저세포암화26례포온병적석사포매표본진행VEGF、VEGFR2、Dl 4、Notch1단백수평적검측,병진행상관성분석。결과 VEGF、VEGFR2、재기저세포암중적표체고우포온병급정상피부조직,차이구유통계학의의(P<0.05)。이Dl 4、Notch1재기저세포암중적표체저우포온병급정상피부조직,차이구유통계학의의(P<0.05)。결론 VEGF、VEGFR2、Dl 4、Notch1여불동충류상피원성피부종류적발전화예후유관。
Objective To compare the expression and relationship of VEGF/VEGFR2, Dl 4/Notch1 signaling pathway in dif erent types of epithelial tumors. Methods The expression of VEGF,VEGFR2,Dl 4 and Notch1 in 60 basal cellcarcinoma tissue and 26 Bowen's disease were observed by using immunohistochemistry. The relationship of VEGF,VEGFR2,Dl 4 and Notch1 were af irmed by correlation analysis. Results VEGF and VEGFR2 expression in the basal cellcarcinom group is higher than the Bowen's disease and the control ( <0.05), while Dl 4 and Notch1 is significantly lower than the the Bowen's disease and the control ( <0.05). VEGF and VEGFR2 expression in the Bowen's disease is higher than the control ( <0.05), for Dll4 and Notch1 is significantly lower than the control ( <0.05).Conclusion VEGF、VEGFR2、Dll4、Notch1 play a rool in the development and prognosis of dif erent epithelial skin tumor.
