CAJ | 학술논문

目的：探讨事件相关电位P300结合简易智能状态量表(MMSE)的测定，在随访评估急性脑梗死患者认知功能方面的应用价值。方法96例急性脑梗死患者在发病后1w内、3个月、6个月时分别行事件相关电位P300及MMSE量表的测定。比较发病后1w内、3M、6M时P300异常、MMSE异常、P300及/或MMSE异常对急性脑梗死后认知功能受损的检出有无差异。结果急性脑梗死发病后1w内、3个月、6个月时P300异常、MMSE异常、P300及/或MMSE异常，差异有统计学意义(<0.01)。结论P300结合MMSE检查，对急性脑梗死后认知功能受损的筛查更敏感，并能有效地随访观察和评估认知功能受损。
목적：탐토사건상관전위P300결합간역지능상태량표(MMSE)적측정，재수방평고급성뇌경사환자인지공능방면적응용개치。방법96례급성뇌경사환자재발병후1w내、3개월、6개월시분별행사건상관전위P300급MMSE량표적측정。비교발병후1w내、3M、6M시P300이상、MMSE이상、P300급/혹MMSE이상대급성뇌경사후인지공능수손적검출유무차이。결과급성뇌경사발병후1w내、3개월、6개월시P300이상、MMSE이상、P300급/혹MMSE이상，차이유통계학의의(<0.01)。결론P300결합MMSE검사，대급성뇌경사후인지공능수손적사사경민감，병능유효지수방관찰화평고인지공능수손。
Objective To explore the valuel of eventrelated potential P300 and mini-mental state examination (MMSE) in the fol ow-up and evaluation of congnitive function after acute cerebral infarction. Methods P300 and MMSE were detected of ninety-six patients after acute cerebral infarction within one week (1W), three month (3M) and six month(6M). The detection of damage of cognitive function was analyzed after acute cerebral infarction. Results The dif erence had statistical significance( <0.01) on anomal-P300, anomal-MMSE, and anomal-P300 and/or anomal-MMSE after acute cerebral infarction within 1W, 3M, and 6M. Conclusion The sensitiveness of detection of P300 combing MMSE can be higher to screen the damage of cognitive function after acute cerebral infarction, and can fol ow-up and evaluate the damage of cognitive function effectual y.