CAJ | 학술논문

目的：研究新疆维族与汉族急性冠脉综合征（ACS）患者血N末端B型利钠肽前体（NT-proBNP）水平的差异。方法：选择2012年5月～2013年8月住院的维族（212例）和汉族（270例） ACS患者，共482例，按ACS分型又分为不稳定型心绞痛（UAP组，234例）、急性ST 段抬高型心肌梗死（STEMI组，166例）、急性非ST段抬高型心肌梗死（NSTEMI组，82例），对各组患者行冠脉造影，检测其 NT-proBNP水平并进行比较。结果：①冠脉造影结果提示维族ACS患者以冠状动脉多支病变为主，明显高于汉族ACS患者（61.32％比40.00％）；②维族ACS患者的NT-proBNP水平显著高于汉族患者[UAP ：383.2（210.3～739.5） pg/ml比168.5（70.6～272.5） pg/ml ，STEMI：1209.5（908～3214） pg/ml 比618.5（231.7～1387） pg/ml、 NSTEMI ：1066（928～3448.25） pg/ml比446.7（252.21～831.92） pg/ml]；③维族不同冠脉病变患者的 NT-proBNP水平均显著高于相应的汉族患者[单支：557.1（125～1956.2） pg/ml比221.7（20～2851） pg/ml ，双支：610.5（174.4～5679.1） pg/ml比421.2（75.2～3401.5） pg/ml ，多支：812.3（154.8～6832.5） pg/ml比648.2（142.4～3850） pg/ml]， P＜0.05～＜0.01。结论：维族ACS患者NT-proBNP水平明显高于汉族患者，可能与遗传、生活习惯、危险因素控制、疾病早期诊治、出院后治疗依从性有关，对于评估患者病情有重要价值。
목적：연구신강유족여한족급성관맥종합정（ACS）환자혈N말단B형리납태전체（NT-proBNP）수평적차이。방법：선택2012년5월～2013년8월주원적유족（212례）화한족（270례） ACS환자，공482례，안ACS분형우분위불은정형심교통（UAP조，234례）、급성ST 단태고형심기경사（STEMI조，166례）、급성비ST단태고형심기경사（NSTEMI조，82례），대각조환자행관맥조영，검측기 NT-proBNP수평병진행비교。결과：①관맥조영결과제시유족ACS환자이관상동맥다지병변위주，명현고우한족ACS환자（61.32％비40.00％）；②유족ACS환자적NT-proBNP수평현저고우한족환자[UAP ：383.2（210.3～739.5） pg/ml비168.5（70.6～272.5） pg/ml ，STEMI：1209.5（908～3214） pg/ml 비618.5（231.7～1387） pg/ml、 NSTEMI ：1066（928～3448.25） pg/ml비446.7（252.21～831.92） pg/ml]；③유족불동관맥병변환자적 NT-proBNP수평균현저고우상응적한족환자[단지：557.1（125～1956.2） pg/ml비221.7（20～2851） pg/ml ，쌍지：610.5（174.4～5679.1） pg/ml비421.2（75.2～3401.5） pg/ml ，다지：812.3（154.8～6832.5） pg/ml비648.2（142.4～3850） pg/ml]， P＜0.05～＜0.01。결론：유족ACS환자NT-proBNP수평명현고우한족환자，가능여유전、생활습관、위험인소공제、질병조기진치、출원후치료의종성유관，대우평고환자병정유중요개치。
Objective : To study plasma N terminal pro brain natriuretic peptide (NT-proBNP ) level difference be-tween Han nationality and Uighur nationality patients with acute coronary syndrome (ACS) in Xinjiang .Methods : A total of 482 Uygur and Han nationalities ACS patients (uighur : 212 cases , han : 270 cases) hospitalized from May 2012 to Aug 2013 were selected . According to ACS types , they were divided into unstable angina pectoris (UAP) group (n = 234) ,acute ST segment elevation myocardial infarction (STEMI) group (n = 166) and acute non- ST segment elevation myocardial infarction (NSTEMI) group (n = 82) .All patients received coronary angiography (CAG) and their NT-proBNP levels were compared .Results : ① CAG results indicated that Uygur nationality ACS patients were mainly multi-vessel coronary disease and the percentage was significantly higher than that of Han na - tionality ACS patients (61.32% vs .40.00% ) ; ② Compared with Han nationality ACS patients ,there were significant rise in NT-proBNP levels [UAP : 168.5 (70.6 ~ 272.5) pg/ml vs .383.2 (210.3 ~ 739.5 ) pg/ml ,STEMI : 618.5 (231.7 ~ 1387) pg/ml vs .1209.5 (908 ~ 3214) pg/ml ,NSTEMI : 446.7 (252.21 ~ 831.92) pg/ml vs .1066 (928 ~ 3448.25) pg/ml] in Uygur nationality ACS patients ; ③ Compared with Han nationality ACS patients ,there were significant rise in NT-proBNP levels [Single vessel : 221.7 (20 ~ 2851) pg/ml vs .557.1 (125 ~ 1956.2) pg/ ml ,double-vessel : 421.2 (75.2 ~ 3401.5) pg/ml vs .610.5 (174.4 ~ 5679.1) pg/ml ,multi-vessel : 648.2 (142.4 ~ 3850) pg/ml vs .812.3 (154.8 ~ 6832.5) pg/ml] in Uygur nationality patients with different number of diseased coronary vessels , P < 0.05 ~ < 0.01 .Conclusion : NT-proBNP level in Uygur nationality ACS patients is significant - ly higher than that of Han nationality patients ,it may be related with hereditas ,living habit ,risk factor control , early diagnosis and treatment of disease ,post-discharge compliance of treatment ,which possesses important value for assessing patient′s condition .