中国医学创新
中國醫學創新
중국의학창신
MEDICAL INNOVATION OF CHINA
2014年
22期
31-33
,共3页
张建磊%李郭飞%常娜%王朝辉%刘大建%贺维亚
張建磊%李郭飛%常娜%王朝輝%劉大建%賀維亞
장건뢰%리곽비%상나%왕조휘%류대건%하유아
尤瑞克林%急性脑梗死%磁共振波谱分析
尤瑞剋林%急性腦梗死%磁共振波譜分析
우서극림%급성뇌경사%자공진파보분석
Human urinary kallidinogenase%Acute cerebralinfarction%Magnetic resonance spectrum
目的：观察尤瑞克林治疗急性脑梗死效果及磁共振波谱特征，探讨尤瑞克林可能的作用机制。方法：发病在24 h内的急性脑梗死患者76例，随机数字表法及随机数余数法分为治疗组38例和对照组38例，对照组接受常规治疗，治疗组在常规治疗的基础上加用尤瑞克林。两组患者均于治疗前、治疗15 d后进行神经功能缺损程度评分及BARTHEL指数评定，并应用磁共振波谱分析入院时（治疗前）、治疗15 d后脑内N-乙酰天门冬氨酸（NAA）和乳酸（Lac）含量。结果：治疗组治疗15 d的神经功能缺损程度评分低于对照组，BARTHEL指数评分高于对照组，比较差异有统计学意义（P<0.01）。磁共振波谱分析显示，治疗后治疗组局部Lac含量低于对照组，NAA含量高于对照组，比较差异有统计学意义（P<0.01）。结论：急性脑梗死患者采用尤瑞克林治疗能够显著改善临床预后，其作用机制可能与加速梗死区Lac清除有关。
目的：觀察尤瑞剋林治療急性腦梗死效果及磁共振波譜特徵，探討尤瑞剋林可能的作用機製。方法：髮病在24 h內的急性腦梗死患者76例，隨機數字錶法及隨機數餘數法分為治療組38例和對照組38例，對照組接受常規治療，治療組在常規治療的基礎上加用尤瑞剋林。兩組患者均于治療前、治療15 d後進行神經功能缺損程度評分及BARTHEL指數評定，併應用磁共振波譜分析入院時（治療前）、治療15 d後腦內N-乙酰天門鼕氨痠（NAA）和乳痠（Lac）含量。結果：治療組治療15 d的神經功能缺損程度評分低于對照組，BARTHEL指數評分高于對照組，比較差異有統計學意義（P<0.01）。磁共振波譜分析顯示，治療後治療組跼部Lac含量低于對照組，NAA含量高于對照組，比較差異有統計學意義（P<0.01）。結論：急性腦梗死患者採用尤瑞剋林治療能夠顯著改善臨床預後，其作用機製可能與加速梗死區Lac清除有關。
목적：관찰우서극림치료급성뇌경사효과급자공진파보특정，탐토우서극림가능적작용궤제。방법：발병재24 h내적급성뇌경사환자76례，수궤수자표법급수궤수여수법분위치료조38례화대조조38례，대조조접수상규치료，치료조재상규치료적기출상가용우서극림。량조환자균우치료전、치료15 d후진행신경공능결손정도평분급BARTHEL지수평정，병응용자공진파보분석입원시（치료전）、치료15 d후뇌내N-을선천문동안산（NAA）화유산（Lac）함량。결과：치료조치료15 d적신경공능결손정도평분저우대조조，BARTHEL지수평분고우대조조，비교차이유통계학의의（P<0.01）。자공진파보분석현시，치료후치료조국부Lac함량저우대조조，NAA함량고우대조조，비교차이유통계학의의（P<0.01）。결론：급성뇌경사환자채용우서극림치료능구현저개선림상예후，기작용궤제가능여가속경사구Lac청제유관。
To observe the therapeutic effect of human urinary kallidinogenase on patients with acute cerebralinfarction(ACI)and the features of magnetic resonance spectrum(MRS),to explore the potential mechanism of action of human urinary kallidinogenase. Method:This study consisted of 76 patients with ACI occurred within 24 h, who were randomized to treatment group and control group. A conventional therapy was offered to patients in the control group;to those in the treatment group,conventional therapy plus human urinary kallidinogenase were offered. Neurologic impairment and BARTHEL were assessed pretherapy and 15 days after therapy. The content of N-acetylaspartate and lactic acid were analyzed by using MRS before and 15 days after treatment. Result:After 15 days of treatment,the score of neurologic impairment was lower in the treatment group than that in the control group,and the BARTHEL index was higher (P<0.01). The MRS showed that after therapy,the level of lactic acid in the treatment group was lower than that in the control group,and N-acetylaspartate was higher(P<0.01). Conclusion:Human urinary kallidinogenase can notably improve the prognosis of patients with ACI,its mechanism is likely to be associated with accelerating clearance of lactic acid in infarct zone.
