中国社区医师
中國社區醫師
중국사구의사
Chinese Community Doctors
2014年
23期
118-119
,共2页
结缔组织病%肺功能%肺动脉高压%间质性肺病
結締組織病%肺功能%肺動脈高壓%間質性肺病
결체조직병%폐공능%폐동맥고압%간질성폐병
Connective tissue diseases%Pulmonary function%Pulmonary arterial hypertension%Interstitial lung disease
目的:探讨结缔组织病(CTD)相关的肺动脉高压(PAH)、间质性肺病(ILD)的肺功能表现。方法:对110例CTD患者肺功能进行分析,包括肺总量(TLC)、用力肺活量(FVC)、1秒用力呼气容积(FEV1.0)、1秒用力呼气容积占用力肺活量比值(FEV1.0/FVC)、肺一氧化碳弥散量(DLCO),肺一氧化碳弥散系数(DLCO/VA)。将对象分为4个亚组:PAH组(26例)、ILD组(35例)、PAH和ILD组(15例)、对照CTD组(34例)。结果:对肺功能各项指标进行方差分析,TLC、FVC、FEV1.0、DLCO、DLCO/VA 差异均有统计学意义(P<0.05);多重比较分析,PAH 组与对照组之间 TLC、FVC、FEV1.0、DLCO、DLCO/VA 差异均有统计学意义(P<0.05),PAH 组和 ILD 组差异无统计学意义。PAH 合并 ILD 组与 ILD组比较,TLC和FVC差异有统计学意义(P<0.05)。与对照组相比,DLco异常率最高。结论:CTD肺受累患者以弥散障碍和限制性通气功能障碍为主,PAH和 ILD 二者在肺功能方面表现无显著差异,当 ILD 合并 PAH时,与单纯 ILD比较,其限制性通气功能障碍加重更明显。
目的:探討結締組織病(CTD)相關的肺動脈高壓(PAH)、間質性肺病(ILD)的肺功能錶現。方法:對110例CTD患者肺功能進行分析,包括肺總量(TLC)、用力肺活量(FVC)、1秒用力呼氣容積(FEV1.0)、1秒用力呼氣容積佔用力肺活量比值(FEV1.0/FVC)、肺一氧化碳瀰散量(DLCO),肺一氧化碳瀰散繫數(DLCO/VA)。將對象分為4箇亞組:PAH組(26例)、ILD組(35例)、PAH和ILD組(15例)、對照CTD組(34例)。結果:對肺功能各項指標進行方差分析,TLC、FVC、FEV1.0、DLCO、DLCO/VA 差異均有統計學意義(P<0.05);多重比較分析,PAH 組與對照組之間 TLC、FVC、FEV1.0、DLCO、DLCO/VA 差異均有統計學意義(P<0.05),PAH 組和 ILD 組差異無統計學意義。PAH 閤併 ILD 組與 ILD組比較,TLC和FVC差異有統計學意義(P<0.05)。與對照組相比,DLco異常率最高。結論:CTD肺受纍患者以瀰散障礙和限製性通氣功能障礙為主,PAH和 ILD 二者在肺功能方麵錶現無顯著差異,噹 ILD 閤併 PAH時,與單純 ILD比較,其限製性通氣功能障礙加重更明顯。
목적:탐토결체조직병(CTD)상관적폐동맥고압(PAH)、간질성폐병(ILD)적폐공능표현。방법:대110례CTD환자폐공능진행분석,포괄폐총량(TLC)、용력폐활량(FVC)、1초용력호기용적(FEV1.0)、1초용력호기용적점용력폐활량비치(FEV1.0/FVC)、폐일양화탄미산량(DLCO),폐일양화탄미산계수(DLCO/VA)。장대상분위4개아조:PAH조(26례)、ILD조(35례)、PAH화ILD조(15례)、대조CTD조(34례)。결과:대폐공능각항지표진행방차분석,TLC、FVC、FEV1.0、DLCO、DLCO/VA 차이균유통계학의의(P<0.05);다중비교분석,PAH 조여대조조지간 TLC、FVC、FEV1.0、DLCO、DLCO/VA 차이균유통계학의의(P<0.05),PAH 조화 ILD 조차이무통계학의의。PAH 합병 ILD 조여 ILD조비교,TLC화FVC차이유통계학의의(P<0.05)。여대조조상비,DLco이상솔최고。결론:CTD폐수루환자이미산장애화한제성통기공능장애위주,PAH화 ILD 이자재폐공능방면표현무현저차이,당 ILD 합병 PAH시,여단순 ILD비교,기한제성통기공능장애가중경명현。
To investigate pulmonary function of pulmonary arterial hypertension(PAH) and interstitial lung disease(ILD) associated with connective tissue disease(CTD).Methods:Analyzed pulmonary function of 110 cases with CTD, including total lung capacity(TLC),forced vital capacity(FVC),forced expiratory volume in one second(FEV1.0),forced expiratory volume in one second to forced vital capacity ratio(FEV1.0/FVC),diffusion capacity of the lung for carbon monoxide(DLCO),lung carbon monoxide diffusion coefficient(DLCO/VA).The subjects were divided into 4 groups:PAH group(26 cases),ILD group(35 cases),PAH group and ILD group(15 cases),CTD control group(34 cases).Results:Variance analysis of each index of pulmonary function,the differences in TLC,FVC,FEV1.0,DLCO,DLCO/VA were statistically significant(P<0.05).Multiple comparison analysis showed that,the differences in TLC,FVC,FEV1.0,DLCO,DLCO/VA between the PAH group and the control group were statistically significantly(P<0.05).The difference in group ILD and group PAH were not obvious.PAH combined with ILD group compared with ILD group,TLC and FVC were significantly different(P<0.05).Compared with the control group,the abnormal rate of Dlco was the highest.Conclusion:The main performance of patients with CTD lung involvement is diffusion barriers and restrictive ventilation dysfunction.Pulmonary function in PAH and ILD have no significant difference.When compared with ILD,restrictive ventilation dysfunction of ILD combined with PAH is more obvious.