CAJ | 학술논문

目的：应用光学相干断层扫描成像(OCT)观察正常人和无糖尿病视网膜病变（NDR)的糖尿病(DM)患者黄斑区视网膜厚度（RT）和视盘周围神经纤维层（RNFL)厚度的改变。方法对照组和NDR组各40只眼，采用OCT测量黄斑区RT和视神经RNFL，记录黄斑部9个分区（A1～A9）RT以及中心凹最低处视网膜厚度（A0）和视盘周围四个区域（颞侧、上方，鼻侧，下方）的RNFL。结果黄斑区RT对比，A3和A5区差异有统计学意义；视盘RNFL对比，上方和颞侧差异具有统计学意义。结论本研究发现NDR糖尿病患者眼底可能存在神经退行性病变，此方法可尽早发现视网膜的损害，为疾病早期诊断、发病机制研究及指导治疗提供帮助。
목적：응용광학상간단층소묘성상(OCT)관찰정상인화무당뇨병시망막병변（NDR)적당뇨병(DM)환자황반구시망막후도（RT）화시반주위신경섬유층（RNFL)후도적개변。방법대조조화NDR조각40지안，채용OCT측량황반구RT화시신경RNFL，기록황반부9개분구（A1～A9）RT이급중심요최저처시망막후도（A0）화시반주위사개구역（섭측、상방，비측，하방）적RNFL。결과황반구RT대비，A3화A5구차이유통계학의의；시반RNFL대비，상방화섭측차이구유통계학의의。결론본연구발현NDR당뇨병환자안저가능존재신경퇴행성병변，차방법가진조발현시망막적손해，위질병조기진단、발병궤제연구급지도치료제공방조。
Objective To detect the change of macular retinal thickness (RT)and retinal nerve fi bre layer (RNFL) thickness in normal subjects and type 2 diabetes patients with no diabetic retinopathy using OCT.Methods Forty eyes of patients with NDR were enrolled. While eyes of normal population (n=40) were also examined. The retinal and RNFL thickness were both measured in two groups by OCT. The RT in A1-A9 areas, the thickness in central fovea and RNFL in the peripheral area (temporal, superior, nasal and inferior) of the macula were all calculated and compared with healthy controls.Results Comparing with the normal eyes, retinal thickness signifi cantly decreased in A3 and A5 and RNFL thickness signifi cantly decreased in the superior and temporal in NDR group.Conclusion This study indicates that there may be a neurodegenerative disease in retinal fundus of diabetic patients. OCT checking could provide help for the early diagnosis, pathogenesis research and treatment of this disease.