CAJ | 학술논문

随着介入心血管学的发展，医用植入材料不断更新，含铜材料的问世为血管介入治疗提供全新的材料。铜是人体必需微量元素，在维持人体正常新陈代谢过程中起着重要作用。血管内皮细胞作为重要的血管屏障，分泌众多生物活性物质，在调节血管张力、保持血液正常流动等方面发挥着重要作用。实验表明内皮细胞功能受损的状态下发现铜离子水平偏离正常，而铜离子水平过高或过低又能加重内皮细胞功能损伤。本文围绕当内皮细胞功能受到各种损伤风险时，阐述铜离子水平在维持血管内皮细胞正常功能发挥的重要作用，为含铜医用材料的应用提供新思路。
수착개입심혈관학적발전，의용식입재료불단경신，함동재료적문세위혈관개입치료제공전신적재료。동시인체필수미량원소，재유지인체정상신진대사과정중기착중요작용。혈관내피세포작위중요적혈관병장，분비음다생물활성물질，재조절혈관장력、보지혈액정상류동등방면발휘착중요작용。실험표명내피세포공능수손적상태하발현동리자수평편리정상，이동리자수평과고혹과저우능가중내피세포공능손상。본문위요당내피세포공능수도각충손상풍험시，천술동리자수평재유지혈관내피세포정상공능발휘적중요작용，위함동의용재료적응용제공신사로。
With the development of interventional cardiovascular science ,medical implant material continually updated .The advent of copper containing material for intravascular interventional treatment provides a new material .Copper as an essential trace element ,plays an important role in maintaining normal metabolic processes .Vascular endothelial cells as an important human vascular barrier ,plays an important role in the regulation of vascular tone ,maintaining normal blood flow ,etc .Experimental results show that under the state of endothelial dysfunction ,levels of copper ions deviate from the normal level ,and if the level is too high or too low the copper ions can aggravate the injury of endothelial cells .This paper focuses on the study when various endothelial cell function is under the risk of being injured ,and reviews an important role that the levels of copper ions plays in maintaining normal function of vascular endothelial cells .It can provide a new idea for the application of medical copper materials .