CAJ | 학술논문

目的：分析脑外伤后凝血功能障碍患者早期应用冷沉淀的疗效，探讨冷沉淀在脑外伤诊治的应用。方法将64例脑外伤伴凝血功能障碍患者随机分为治疗组34例和对照组30例。对照组患者予常规止血、脱水、预防癫痫、营养神经、预防癫痫及对症治疗，治疗组患者加用冷沉淀止血。统计并分析进展性脑出血的发生率、凝血指标及患者的预后。结果治疗组进展性脑出血的发生率为17.65%，明显低于对照组的30.00%（ P ﹤0.05）。治疗组患者输冷沉淀后凝血指标有明显改善（ P ﹤0.05），患者预后比对照组更好（ P ﹤0.05）。结论冷沉淀能改善凝血功能障碍，减少进展性脑出血的发生，最终改善患者预后。
목적：분석뇌외상후응혈공능장애환자조기응용랭침정적료효，탐토랭침정재뇌외상진치적응용。방법장64례뇌외상반응혈공능장애환자수궤분위치료조34례화대조조30례。대조조환자여상규지혈、탈수、예방전간、영양신경、예방전간급대증치료，치료조환자가용랭침정지혈。통계병분석진전성뇌출혈적발생솔、응혈지표급환자적예후。결과치료조진전성뇌출혈적발생솔위17.65%，명현저우대조조적30.00%（ P ﹤0.05）。치료조환자수랭침정후응혈지표유명현개선（ P ﹤0.05），환자예후비대조조경호（ P ﹤0.05）。결론랭침정능개선응혈공능장애，감소진전성뇌출혈적발생，최종개선환자예후。
Objective To analyze the effect of early using cryoprecipitate in treating coagulopathy after traumatic brain injury and to in-vestigate its application in the diagnosis and treatment of brain trauma. Methods 64 patients with traumatic brain injury complicating coagulopathy were randomly divided into the therapy group(34 cases) and the control group(30 cases) . The control group were treated with the conventional therapy of hemostasis, dehydration, preventing epilepsy, trophic nerve and symptomatic treatment, the therapy group was added with cryoprecipitate on the basis of conventional therapy. The occurrence rate of progressive cerebral hemorrhage, coagulation indexes and prognosis were statistically analyzed and compared between the two groups. Results The occurrence rate of progressive cerebral hemorrhage was 17. 65% in the therapy group, which was significantly lower than 30. 00% in the control group( P ﹤ 0. 05); the coagulation indexes after treatment in the therapy group were obviously improved than before treatment( P ﹤ 0. 05); the therapy group had better prognosis than the control group( P ﹤ 0. 05 ) . Conclusion Cryoprecipitate can improve coagulopathy, reduce the occurrence of progressive cerebral hemorrhage and ultimately improve the patients' prognosis.