中国药业
中國藥業
중국약업
CHINA PHARMACEUTICALS
2014年
15期
107-108,109
,共3页
潘华英%王爱华%赵静%刘荣英%江艳
潘華英%王愛華%趙靜%劉榮英%江豔
반화영%왕애화%조정%류영영%강염
卡培他滨%5 - 氟尿嘧啶%调强适形放射治疗%三维适形放射治疗
卡培他濱%5 - 氟尿嘧啶%調彊適形放射治療%三維適形放射治療
잡배타빈%5 - 불뇨밀정%조강괄형방사치료%삼유괄형방사치료
capecitabine%5 - fluorouracil%intensity moducated radiation therapy(IMRT)%three dimensiond comformal radiotherapy(3D - CRT)
目的：观察卡培他滨联合调强适形放射治疗(IMRT)对老年食管癌患者根治术后局部复发的影响。方法选择2010年3月至2012年3月就诊并接受食管癌根治术的局部复发患者126例，随机分为对照组和治疗组，各63例。对照组给予5-氟尿嘧啶500 mg / d 和三维适形放射治疗（3D - CRT），2 Gy / d，每天1次，每周5次；治疗组给予卡培他滨1000 mg / m2，口服2次，1~14 d 联合 IMRT，50~65 Gy，以3周为1个周期，两组疗程均为6周，观察并记录近期疗效、转移复发率、远期疗效的指标及药品不良反应和放射反应。结果治疗组总有效率为90.48%，显著高于对照组的77.78%（ P ﹤0.05）；两组治疗转移复发率差异无统计学意义；治疗组远期疗效明显优于对照组（ P ﹤0.05）；两组患者不良反应较轻且在可控范围内，两组患者1~2度骨髓抑制、1~2度胃肠道反应、1~2度手足综合征发生率无明显差异，治疗组放射性食管炎、放射性肺炎发生率均显著低于对照组（ P ﹤0.05）。结论卡培他滨联合 IMRT 在老年食管癌患者根治术后局部复发的治疗中，近期有效率和局部控制率高，远期疗效好，不良反应较轻且放射反应较发生率低，值得临床推广。
目的：觀察卡培他濱聯閤調彊適形放射治療(IMRT)對老年食管癌患者根治術後跼部複髮的影響。方法選擇2010年3月至2012年3月就診併接受食管癌根治術的跼部複髮患者126例，隨機分為對照組和治療組，各63例。對照組給予5-氟尿嘧啶500 mg / d 和三維適形放射治療（3D - CRT），2 Gy / d，每天1次，每週5次；治療組給予卡培他濱1000 mg / m2，口服2次，1~14 d 聯閤 IMRT，50~65 Gy，以3週為1箇週期，兩組療程均為6週，觀察併記錄近期療效、轉移複髮率、遠期療效的指標及藥品不良反應和放射反應。結果治療組總有效率為90.48%，顯著高于對照組的77.78%（ P ﹤0.05）；兩組治療轉移複髮率差異無統計學意義；治療組遠期療效明顯優于對照組（ P ﹤0.05）；兩組患者不良反應較輕且在可控範圍內，兩組患者1~2度骨髓抑製、1~2度胃腸道反應、1~2度手足綜閤徵髮生率無明顯差異，治療組放射性食管炎、放射性肺炎髮生率均顯著低于對照組（ P ﹤0.05）。結論卡培他濱聯閤 IMRT 在老年食管癌患者根治術後跼部複髮的治療中，近期有效率和跼部控製率高，遠期療效好，不良反應較輕且放射反應較髮生率低，值得臨床推廣。
목적：관찰잡배타빈연합조강괄형방사치료(IMRT)대노년식관암환자근치술후국부복발적영향。방법선택2010년3월지2012년3월취진병접수식관암근치술적국부복발환자126례，수궤분위대조조화치료조，각63례。대조조급여5-불뇨밀정500 mg / d 화삼유괄형방사치료（3D - CRT），2 Gy / d，매천1차，매주5차；치료조급여잡배타빈1000 mg / m2，구복2차，1~14 d 연합 IMRT，50~65 Gy，이3주위1개주기，량조료정균위6주，관찰병기록근기료효、전이복발솔、원기료효적지표급약품불량반응화방사반응。결과치료조총유효솔위90.48%，현저고우대조조적77.78%（ P ﹤0.05）；량조치료전이복발솔차이무통계학의의；치료조원기료효명현우우대조조（ P ﹤0.05）；량조환자불량반응교경차재가공범위내，량조환자1~2도골수억제、1~2도위장도반응、1~2도수족종합정발생솔무명현차이，치료조방사성식관염、방사성폐염발생솔균현저저우대조조（ P ﹤0.05）。결론잡배타빈연합 IMRT 재노년식관암환자근치술후국부복발적치료중，근기유효솔화국부공제솔고，원기료효호，불량반응교경차방사반응교발생솔저，치득림상추엄。
Objective To observe the effect of capecitabine combined with the intensity modulated radiation therapy(IMRT) on local re-currence after radical operation in elderly patients with esophageal cancer. Methods 126 patients with local recurrence after esophageal cancer radical resection in our hospital from March 2010 to March 2012 were selected and randomly divided into the treatment group and the control group, 63 cases in each group. The control group received 5 - fluorouracil 500 mg / d and the three - dimensional confor-mal radiotherapy(3D - CRT), 2 Gy / day, once daily, 5 times a week; the treatment group received capecitabine 1 000 mg / m2, orally twice daily on 1 - 14 d, and combined with IMRT, 50 - 65 Gy, 3 weeks as 1 cycle. Both groups had the same treatment course of 6 weeks. The short term effect, metastasis and recurrence rates, indicators of long - term efficacy, adverse drug reactions and radiation reaction were ob-served and recorded. Results The total effective rate was 90. 48% in the treatment group, which was significantly higher than 77. 78%in the control group( P ﹤ 0. 05 ); the metastatic recurrence rate in the two groups had no statistically significant difference; the long - term efficacy in the treatment group was superior to the control group( P ﹤ 0. 05 ); the adverse reactions in the two groups were mild and within the controllable range, the occurrence rates of 1 - 2 degree of myelosuppression, 1 - 2 degree of gastrointestinal reactions and 1 -2 degree of hand - foot syndrome had no statistically significant difference, the occurrence rate of radiation esophagitis and radiation pneumonitis in the treatment group were significantly lower than that in the control group( P ﹤ 0. 05) . Conclusion Capecitabine com-bined with conformal IMRT in treating local recurrence after radical operation in elderly patients with esophageal cancer has high ef-fective rate in the short term therapy, high local control rate, good long - term efficacy, mild adverse reactions and low occurrence rate of radiation reactions, which is worthy of clinical promotion.
