CAJ | 학술논문

目的：评价双龙保心方对大鼠急性心肌梗死的治疗作用。方法冠状动脉结扎法制备大鼠急性心肌梗死模型；造模后10 min 十二指肠给药；造模后4 h，取血测定血清中肌酸激酶（CK）、乳酸脱氢酶（LDH）、超氧化物歧化酶（SOD）和丙二醛（MDA）水平；取出心脏，切片，氯化硝基四氮唑蓝（N - BT）染色，测定心肌梗死面积。结果所有给药大鼠组的血清 CK，LDH，SOD，MDA 水平与模型组比较均无显著性差异。与模型组比较，双龙保心方高、中剂量组的心肌梗死面积显著降低（ P ﹤0.05）。结论双龙保心方对大鼠急性心肌梗死有显著保护作用。
목적：평개쌍룡보심방대대서급성심기경사적치료작용。방법관상동맥결찰법제비대서급성심기경사모형；조모후10 min 십이지장급약；조모후4 h，취혈측정혈청중기산격매（CK）、유산탈경매（LDH）、초양화물기화매（SOD）화병이철（MDA）수평；취출심장，절편，록화초기사담서람（N - BT）염색，측정심기경사면적。결과소유급약대서조적혈청 CK，LDH，SOD，MDA 수평여모형조비교균무현저성차이。여모형조비교，쌍룡보심방고、중제량조적심기경사면적현저강저（ P ﹤0.05）。결론쌍룡보심방대대서급성심기경사유현저보호작용。
Objective To evaluate the curative effect of Shuanglongbaoxin formula on acute myocardial infarction in rat. Methods Acute myocardial infarct rat model was established by the coronary artery ligation; at 10 min after constructing the rat model, the drug was in-traduodenally administrated; at 4 h after modeling, blood was collected to determine the levels of creatine kinase(CK), lactate dehydroge-nase(LDH), superoxide dismutase(SOD) and malondialdehyde(MDA). The rat heart was taken for preparing the sections and staining by nitrotetrazolium blue chloride(N - BT) . Then myocardial infarcted areas were detected. Results The levels of serum CK, LDH, SOD and MDA in all medication groups had no statistically significant differences compared with the model group, the myocardial infarcted area in Shuanglongbaoxin formula groups at the high dose and the middle dose was significantly reduced compared with the model group ( P ﹤ 0. 05 ). Conclusion Shuanglongbaoxin formula has the significant protective effect on acute myocardial ischemia in rat.