上海医药
上海醫藥
상해의약
SHANGHAI MEDICAL & PHARMACEUTICAL JOURNAL
2014年
15期
46-48
,共3页
冠心病%血清C反应蛋白%胱抑素C%生化检验指标
冠心病%血清C反應蛋白%胱抑素C%生化檢驗指標
관심병%혈청C반응단백%광억소C%생화검험지표
coronary heart disease%serum C-reactive protein%cystatin C%biochemical test indicators
目的:探讨冠心病患者血清C反应蛋白(CRP)、胱抑素C(CysC)等生化检验指标测定的临床意义。方法:选取2011年2月-2013年2月在本院就诊的80例冠心病患者作为观察组[其中急性心肌梗死(AMI亚组)33例,不稳定型心绞痛(UAP亚组)23例,稳定型心绞痛(SAP亚组)24例],将同期80例健康体检者作为对照组,采用生化分析仪检测全部受试对象的生化检验指标,包括:血清C反应蛋白(CRP)、胱抑素C(CysC)、同型半胱氨酸(Hcy)、血糖(GLU)、总蛋白(TP)、尿素氮(BUN)、肌酐(Cr)等,并进行统计学分析。结果:两组受试者的GLU、TP、BUN、Cr指标差异无统计学意义(P>0.05),但观察组患者CRP、CysC、Hcy水平明显高于对照组(P<0.05)。在不同类型冠心病的比较中发现AMI亚组患者血清Hcy和CRP水平明显高于UAP亚组和SAP亚组(P<0.05)。AMI组亚患者血清CysC水平明显低于UAP亚组和SAP亚组(P<0.05)。结论:CRP、CysC、Hcy水平的检测可以作为预测冠心病的发生和发展的指标,值得临床推广使用。
目的:探討冠心病患者血清C反應蛋白(CRP)、胱抑素C(CysC)等生化檢驗指標測定的臨床意義。方法:選取2011年2月-2013年2月在本院就診的80例冠心病患者作為觀察組[其中急性心肌梗死(AMI亞組)33例,不穩定型心絞痛(UAP亞組)23例,穩定型心絞痛(SAP亞組)24例],將同期80例健康體檢者作為對照組,採用生化分析儀檢測全部受試對象的生化檢驗指標,包括:血清C反應蛋白(CRP)、胱抑素C(CysC)、同型半胱氨痠(Hcy)、血糖(GLU)、總蛋白(TP)、尿素氮(BUN)、肌酐(Cr)等,併進行統計學分析。結果:兩組受試者的GLU、TP、BUN、Cr指標差異無統計學意義(P>0.05),但觀察組患者CRP、CysC、Hcy水平明顯高于對照組(P<0.05)。在不同類型冠心病的比較中髮現AMI亞組患者血清Hcy和CRP水平明顯高于UAP亞組和SAP亞組(P<0.05)。AMI組亞患者血清CysC水平明顯低于UAP亞組和SAP亞組(P<0.05)。結論:CRP、CysC、Hcy水平的檢測可以作為預測冠心病的髮生和髮展的指標,值得臨床推廣使用。
목적:탐토관심병환자혈청C반응단백(CRP)、광억소C(CysC)등생화검험지표측정적림상의의。방법:선취2011년2월-2013년2월재본원취진적80례관심병환자작위관찰조[기중급성심기경사(AMI아조)33례,불은정형심교통(UAP아조)23례,은정형심교통(SAP아조)24례],장동기80례건강체검자작위대조조,채용생화분석의검측전부수시대상적생화검험지표,포괄:혈청C반응단백(CRP)、광억소C(CysC)、동형반광안산(Hcy)、혈당(GLU)、총단백(TP)、뇨소담(BUN)、기항(Cr)등,병진행통계학분석。결과:량조수시자적GLU、TP、BUN、Cr지표차이무통계학의의(P>0.05),단관찰조환자CRP、CysC、Hcy수평명현고우대조조(P<0.05)。재불동류형관심병적비교중발현AMI아조환자혈청Hcy화CRP수평명현고우UAP아조화SAP아조(P<0.05)。AMI조아환자혈청CysC수평명현저우UAP아조화SAP아조(P<0.05)。결론:CRP、CysC、Hcy수평적검측가이작위예측관심병적발생화발전적지표,치득림상추엄사용。
To explore the clinical signiifcance of the determination of biochemical indicators such as serum C-reactive protein (CRP), cystatin C (CysC) in patients with coronary heart disease (CHD). Methods: Eighty patients with coronary heart disease were selected as an observation group including AMI subgroup 33 cases, UAP subgroup 23 cases and SAP subgroup 24 cases, and 80 people with healthy examination as a control group. Biochemical indicators including CRP, CysC, homocysteine (Hcy), glucose (GLU), total protein (TP), blood urea nitrogen (BUN), creatinine (Cr) were detected in all subjects by biochemical analyzer, and were statistically analyzed. Results:There were no statistically signiifcant differences in GLU, TP, BUN, Cr indicators between two groups (P>0.05) while CRP, CysC, Hcy levels were obviously higher in the observation group than in the control group (P<0.05). In a comparison of different type of CHD, serum Hcy and CRP levels of patients were significantly higher in AMI subgroup than in UAP and SAP subgroups (P<0.05) while serum CysC level was lower in AMI subgroup than in UAP and SAP subgroups (P<0.05). Conclusion:Determination of CRP, CysC, Hcy levels can be used as indicators for the prognosis of the occurrence and development of coronary heart disease, which is worthy of clinical use.