CAJ | 학술논문

近年来，高尿酸血症和痛风的发病率呈逐年升高趋势，已引起人们的广泛重视。最近研究发现，尿酸盐转运体的基因变异与高尿酸血症和痛风的发生高度相关，在疾病的发病机制中起着重要的作用。本文介绍ABCG2的2个单核苷酸多态性Q141K和Q126X的功能以及与高尿酸血症和痛风发生的关系。
근년래，고뇨산혈증화통풍적발병솔정축년승고추세，이인기인문적엄범중시。최근연구발현，뇨산염전운체적기인변이여고뇨산혈증화통풍적발생고도상관，재질병적발병궤제중기착중요적작용。본문개소ABCG2적2개단핵감산다태성Q141K화Q126X적공능이급여고뇨산혈증화통풍발생적관계。
Hyperuricemia and gout incidence have been steadily increased year by year, which has attracted widespread attention. Recent studies have shown that the variation of the gene responsible for urate transporter is highly correlated with hyperuricemia and gout and plays a very important role in the pathogenesis of the diseases. This article focuses on the function of two single nucleotide polymorphism Q141K and Q126X in ABCG2 and their relationship with hyperuricemia and gout.