CAJ | 학술논문

目的分析阿莫西林分散片在治疗上呼吸道感染患者时药物代谢动力学变化。方法选取156例上呼吸道感染患者为研究对象，采用数字表法随机分为观察组和对照组各78例，对照组口服阿莫西林胶囊，观察组口服阿莫西林分散片。监测两组患者的血药浓度及治疗效果。结果观察组患者服药后，最大血药浓度（732.5±60.84）μg/L、血药浓度下面积（6340.2±170.36）明显高于对照组（ P ﹤0.05），达峰时间（2.7±0.65）h、分布半衰期（4.6±1.19）h明显快于对照组（ P ﹤0.05）；观察组总有效率（96.15%）明显高于对照组（ P ﹤0.05）。结论采用阿莫西林分散片治疗上呼吸道感染患者，血药浓度高、达峰时间短、起效快、疗效确切，有较高的临床应用价值。
목적분석아막서림분산편재치료상호흡도감염환자시약물대사동역학변화。방법선취156례상호흡도감염환자위연구대상，채용수자표법수궤분위관찰조화대조조각78례，대조조구복아막서림효낭，관찰조구복아막서림분산편。감측량조환자적혈약농도급치료효과。결과관찰조환자복약후，최대혈약농도（732.5±60.84）μg/L、혈약농도하면적（6340.2±170.36）명현고우대조조（ P ﹤0.05），체봉시간（2.7±0.65）h、분포반쇠기（4.6±1.19）h명현쾌우대조조（ P ﹤0.05）；관찰조총유효솔（96.15%）명현고우대조조（ P ﹤0.05）。결론채용아막서림분산편치료상호흡도감염환자，혈약농도고、체봉시간단、기효쾌、료효학절，유교고적림상응용개치。
Objective To analyze pharmacokinetic changes of amoxicillin dispersible tablets in the treatment of patients with upper respir-atory tract infection. Methods One hundred fifty-six cases of upper respiratory tract infection were randomly divided into observation group( n=78)and control group(n=78)using digital table method. Control group was treated with oral amoxicillin capsules,observation group was trea-ted with oral amoxicillin dispersible tablets. Plasma drug concentration and therapeutic effects of two groups of patients were monitored. Results The peak concentration(732. 5 ± 60. 84μg/L)and AUC(6 340. 2 ± 170. 36)were significantly higher in observation group than control group( P ﹤0. 05). The Tmax(2. 7 ± 0. 65 h)and half-life(4. 6 ± 1. 19 h)were obviously shorter than the control group( P ﹤0. 05). The total ef-fective rate of observation group(96. 15%)was significantly higher than the control group( P ﹤0. 05). Conclusion For the treatment of pa-tients with upper respiratory tract infection,amoxicillin dispersible tablet displays higher plasma drug concentration and shorter Tmax in comparison with amoxicillin capsules.